Promoting effects of various agents in rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine |
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| Authors: | Y Kurata M Asamoto A Hagiwara T Masui S Fukushima |
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| Affiliation: | 1. Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA;2. Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA;3. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY 40202, USA;4. The Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA;5. The Jewish Hospital Liver Transplant Program, Louisville, KY 40202, USA;6. The Proteomics Core, University of Louisville School of Medicine, Louisville, KY 40202, USA;7. Hepatobiology & Toxicology Center, University of Louisville School of Medicine, Louisville, KY 40202, USA;8. University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY 40202, USA;9. University of Louisville Superfund Research Program, University of Louisville, Louisville, KY 40202, USA;1. Department of Biochemistry, Panjab University, Chandigarh, India;2. Department of Biophysics, Panjab University, Chandigarh, India;1. School of PE, Henan University of Science and Technology, Luoyang 471023, China;2. Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital (College of Clinical Medicine) of Henan University of Science and Technology, Luoyang 471003, China |
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| Abstract: | The effects of various chemicals on the development of neoplastic lesions in the urinary bladder were investigated in male F344 rats given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) as an initiator in their drinking water for 4 weeks. The compounds tested, indomethacin, acemetacin, epsilon-aminocaproic acid (EACA), diphenyl, allopurinol and acetaminophen (AAP), were added to the diet or drinking water for 32 weeks, and all animals were killed at the end of week 36. Of the chemicals tested, only diphenyl significantly increased the incidences and average numbers (per 10 cm basement membrane) of papillary or nodular hyperplasias (PN hyperplasia), papillomas and carcinomas of the urinary bladder over those in animals treated with BBN alone. These findings show that diphenyl is a promoter of urinary bladder carcinogenesis in male F344 rats. |
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