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| KL-6 mucin expression in carcinoma of the ampulla of Vater： Association with cancer progression | |
| 作者姓名： | Tang W Inagaki Y Kokudo N Guo Q Seyama Y Nakata M Imamura H Sano K Sugawara Y Makuuchi M |
| 作者单位： | Department of Applied Biochemistry Tokai University Hiratsuka Kanagawa 259-1292 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan,Department of Applied Biochemistry and Institute of Glycotechnology Tokai University Hiratsuka Kanagawa 259-1292 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan,Hepato-Biliary-Pancreatic Surgery Division Department of Surgery Graduate School of Medicine the University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655 Japan |
| 基金项目： | Supported by Grants-in-aid From the Ministry of Education, Science, Sports, and Culture of Japan and a grant for Hi-Tech Research from Tokai University |
| 摘 要： | AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P=0.020), pancreatic invasion (P=0.016), duodenal invasion (P= 0.034), and advanced stage of TNM clinical classification (P=0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P=0.029). CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. |
| 关 键 词： | KL-6粘液素 基因表达 癌症 疾病分类 |
| 收稿时间： | 2005 Mar 1 |
KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression |
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| Tang W,Inagaki Y,Kokudo N,Guo Q,Seyama Y,Nakata M,Imamura H,Sano K,Sugawara Y,Makuuchi M.KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression[J].World Journal of Gastroenterology,2005,11(35):5450-5454. | |
| Authors: | Tang Wei Inagaki Yoshinori Kokudo Norihiko Guo Qian Seyama Yasuji Nakata Munehiro Imamura Hiroshi Sano Keiji Sugawara Yasuhiko Makuuchi Masatoshi |
| Institution: | 1. Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery,Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo,Bunkyo-ku, Tokyo 113-8655, Japan 2. Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan 3. Department of Applied Biochemistry and Institute of Glycotechnology, Tokai University, Hiratsuka,Kanagawa 259-1292, Japan |
| Abstract: | AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P=0.020), pancreatic invasion (P=0.016), duodenal invasion (P= 0.034), and advanced stage of TNM clinical classification (P=0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P=0.029). CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. |
| Keywords: | KL-6 mucin Carcinoma of the ampulla of Vater Invasion Metastasis Prognosis |
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