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Multiple sites of action for anxiogenic drugs: Behavioural,electrophysiological and biochemical correlations |
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| Authors: | Sharon Pellow Sandra E. File |
| Affiliation: | (1) MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX London, UK |
| Abstract: | This review describes animal models of anxiety that are able to identify an anxiogenic drug effect. Evidence is reviewed for the anxiogenic action of several drugs that act at the GABA-benzodiazepine-chloride ionophore complex in the brain. The effects of their combinations with various other drugs thought to act at the same sites are discussed. The classification of these drugs on the basis of their behavioural profiles is compared with their classification based on biochemical and electrophysiological studies. |
| Keywords: | Anxiety Social interaction Conflict Drug discrimination Ro 15-1788 CGS 8216 |
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