Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: Relation to dysplasia and DNA aneuploidy |
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Authors: | Per Karlén Eric Young Olle Broström Robert Löfberg Bernhard Tribukait Åke Öst Carol Bodian Steven Itzkowitz |
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Institution: | *Division of Gastroenterology, Department of Medicine, Söder Hospital, Karolinska Institute, Stockholm, Sweden;‡Gastrointestinal Research Laboratory, Department of Medicine, Mount Sinai School of Medicine, New York, New York;§Department of Gastroenterology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden;∥Department of Radiobiology, Karolinska Institute, Stockholm, Sweden;¶Department of Pathology and Cytology, Medilab, Täby, Stockholm, and Karolinska Institute, Stockholm, Sweden;#Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York |
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Abstract: | Background & Aims: Expression of the mucin-associated carbohydrate antigen sialyl-Tn (STn) and DNA aneuploidy has each been shown to correlate with malignant transformation in patients with sporadic colon cancer and in those with ulcerative colitis (UC). This study aimed to determine how STn expression topographically and temporally relates to aneuploidy and neoplasia in patients with long-standing UC. Methods: Twenty-six patients enrolled in a cancer surveillance program were studied, and 1691 mucosal specimens from repeated colonoscopies and colectomies were assessed in a standardized, prospective fashion for the presence of dysplasia, aneuploidy, and STn antigen. Results: STn was expressed in 47% of specimens from 6 patients who underwent colectomy for dysplasia and 7% of specimens from 6 well-matched patients who underwent surgery for medical intractability. Seven other patients who never developed dysplasia or aneuploidy expressed STn in 6% of biopsy specimens. STn expression was independent of aneuploidy in colons both with and without dysplasia. Of 5 patients with aneuploidy but without dysplasia, 4 expressed STn earlier than aneuploidy. Conclusions: In UC, STn antigen and DNA aneuploidy are independent markers of neoplastic transformation. Determination of STn expression may complement dysplasia and aneuploidy for identification of risk for colonic neoplasia in UC.GASTROENTEROLOGY 1998;115:1395-1404 |
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Keywords: | Abbreviations: FCM flow cytometry MAb monoclonal antibody STn sialyl-Tn |
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