Paramyosin: a candidate vaccine antigen against Schistosoma japonicum |
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Authors: | BERNADETTE L RAMIREZ JONATHAN D KURTIS PETER M WIEST PERCIVAL ARIAS FE ALIGUI LUZ ACOSTA PIERRE PETERS GRICHARD OLDS |
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Institution: | Research Institute for Tropical Medicine, Metro Manila, Philippines; International Health Institute, Brown University, Providence, RI 02912, USA |
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Abstract: | Paramyosin, a 97 kDa myofibrillar protein, is a candidate vaccine antigen for prevention of infection with the human parasite Schistosoma mansoni . To determine if paramyosin would also induce protection against Schistosoma japonicum , paramyosin was biochemically purified from S. japonicum adult worms. SDS-PAGE demonstrated a single protein with a molecular weight of 97 kDa. In four separate experiments, vaccination of mice with S. japonicum paramyosin without adjuvant induced significant resistance (62%–86%, P < 0.001) against cercarial challenge as compared to controls. These data suggest that S. japonicum paramyosin may represent a candidate vaccine for immunization against schistosomiasis japonica. |
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Keywords: | Schistosoma japonicum trematode paramyosin immunity |
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