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Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons |
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| Authors: | Hugh D Piggins David J Cutler Benjamin Rusak |
| Institution: | aDepartments of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada;bAnatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada;cPharmacology, Dalhousie University, Halifax, Nova Scotia, Canada |
| Abstract: | Ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-d-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons. |
| Keywords: | Substance P Tachykinin Suprachiasmatic nucleus Electrophysiology Circadian rhythm |
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