| 受体肝纤维化大鼠小体积肝移植模型的建立 |
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| 引用本文： | 苏明,陈永亮,万钧. 受体肝纤维化大鼠小体积肝移植模型的建立[J]. 军医进修学院学报, 2014, 0(3): 270-272 |
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| 作者姓名： | 苏明 陈永亮 万钧 |
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| 作者单位： | [1] 解放军总医院 肝胆外科,北京100853 [2] 香港大学肝病研究中心外科系,香港 |
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| 摘 要： | 目的：建立稳定的受体肝纤维化大鼠小体积肝移植模型。方法采用肝纤维化的SD大鼠，行56.3%比例的小体积肝移植12例，95.8%比例的全肝移植12例。结果成功构建了受体肝纤维化大鼠小体积肝移植模型；受体肝纤维化大鼠的全肝移植组术后24 h肝功能、7 d生存率明显优于小体积肝移植组（P＜0.05）。结论成功建立了受体肝纤维化大鼠小体积肝移植模型，可作为相关研究的有效动物实验平台。
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| 关 键 词： | 肝移植 肝纤维化 小体积供肝 动物模型 |
Establishment of small-size liver transplantation model for cirrhotic rats |
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| SU Ming,CHEN Yong-liang,WAN Jun. Establishment of small-size liver transplantation model for cirrhotic rats[J]. Academic Journal of Pla Postgraduate Medical School, 2014, 0(3): 270-272 |
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| Authors: | SU Ming CHEN Yong-liang WAN Jun |
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| Affiliation: | 1.Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, china; 2Department of Cardiosurgery, Hepatic Research Center, Hong Kong University, Hong Kong, China) |
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| Abstract: | Objective To establish the small-size liver transplantation model for cirrhotic rats. Methods Of the 24 SD cirrhotic rats,12 underwent small-size liver transplantation （56.3%） and 12 underwent whole liver transplantation （95.8%）. Results The small-size liver transplantation model was successfully established for cirrhotic rats. The liver function 24 h after operation and the 7-day survival rate were significantly higher in whole liver transplantation group than in small-size liver transplantation group （P＆lt;0.05）. Conclusion The small-size liver transplantation model for cirrhotic rats can be used as an animal experiment platform for liver transplantation-related research. |
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| Keywords: | liver transplantation liver fibrosis small-size liver donor liver animal model |
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