| 肿瘤相关基因TXNDC5的研究进展 |
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| 引用本文： | 李春梅,张林,李楠.肿瘤相关基因TXNDC5的研究进展[J].军医进修学院学报,2014(3):295-298. |
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| 作者姓名： | 李春梅 张林 李楠 |
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| 作者单位： | 解放军第309医院 消化科,北京100091 |
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| 基金项目： | 首都卫生发展科研专项项目（2011-5007-01） |
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| 摘 要： | TXNDC5基因定位于染色体6p24.3上并且具有编码蛋白二硫键异构酶的功能。其所编码的蛋白含有3个硫氧还蛋白结构域并且可以补偿二硫键异构酶在酵母中功能的损失。研究发现TXNDC5基因在一些癌组织中的表达水平明显高于正常组织。本文主要就TXNDC5在肿瘤领域的最新研究进展进行综述。
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| 关 键 词： | TXNDC5基因 蛋白二硫键异构酶 肿瘤 |
Advances in tumor-associated gene thioredoxin domain containing protein 5 |
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| LI Chun-mei,ZHANG Lin,LI Nan.Advances in tumor-associated gene thioredoxin domain containing protein 5[J].Academic Journal of Pla Postgraduate Medical School,2014(3):295-298. |
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| Authors: | LI Chun-mei ZHANG Lin LI Nan |
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| Institution: | ( Department of Gastroenterology, Chinese PLA 309 Hospital, Beijing 100091, China) |
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| Abstract: | Thioredoxin domain containing protein 5 （TXNDC5） is located on chromosome 6p24 and encodes a protein-disulfide isomerase containing 3 thioredoxin motifs which can compensate for a loss of PDI function in yeast. It has been shown that the expression level of TXNDC5 gene is higher in carcinoma tissues than in normal tissues. Following is a review of the advances in tumor-associated TXNDC5. |
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| Keywords: | thioredoxin domain containing protein 5 protein disulfide isomerase neoplasms |
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