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芳基三氮烯甲氧嘧啶对小鼠Lewis肺癌转移的预防作用及形态学观察
引用本文:江春,张志尧,苏长海,李德华. 芳基三氮烯甲氧嘧啶对小鼠Lewis肺癌转移的预防作用及形态学观察[J]. 药学学报, 1986, 21(8): 623-626
作者姓名:江春  张志尧  苏长海  李德华
作者单位:天津医药科学研究所(江春,张志尧,苏长海),天津医药科学研究所(李德华)
摘    要:前文报道,芳基三氮烯甲氧嘧啶(ATMP)可选择性地抑制Lewis肺癌的自发性转移,其作用环节可能是抑制原发瘤细胞的脱落。为了探讨ATMP抗转移的实际应用价值及作用机理,本文以Lewis肺癌为模型,模拟临床手术加化疗的治疗方案进行实验研究,并观察了ATMP对原发瘤的形态学改变以及对LA-795肺腺癌自发性转移的作用。

关 键 词:芳基三氮烯甲氧嘧啶  Lewis肺癌  LA-795肺癌  抗转移
收稿时间:1985-10-14

PROPHYLACTICLY ANTIMETASTATIC EFFECTS OF ARYLTRIAZENE METHOXYPYRIMIDINE ON LEWIS LUNG CARCINOMA AND ITS HISTOLOGICAL AND ULTRASTRUCTURAL OBSERVATION
JIANG Chun,ZHANG Zhi-Yao,SU Chang-Hai,and LI De-Hua. PROPHYLACTICLY ANTIMETASTATIC EFFECTS OF ARYLTRIAZENE METHOXYPYRIMIDINE ON LEWIS LUNG CARCINOMA AND ITS HISTOLOGICAL AND ULTRASTRUCTURAL OBSERVATION[J]. Acta pharmaceutica Sinica, 1986, 21(8): 623-626
Authors:JIANG Chun  ZHANG Zhi-Yao  SU Chang-Hai  and LI De-Hua
Abstract:The antimetastatic effects of aryltriazene methoxypyrimidine (ATMP) were investigated in mice implanted intramuscularly with Lewis lung carcinoma in the calf of the hind leg. Primary tumor was removed surgically by amputation in mice treated with the tested compounds preoperatively and postoperatively. The results showed that amputation alone on the 9th or 11th day after tumor implantation did not prevent pulmonary metastasis. Prophylactically antimetastatic effects on spontanous metastasis were observed with the treatment of ATMP when neoplasm spreading had not taken place. It was indicated, with histological examination, that after ATMP administration, the cancer cells of primary tumor entering blood and lymphatic vessels were prevented. Observation with electron microscope showed some ultrastructural changes including the strengthening of the gap junction, more abundant of collagen fibrils and lack of microfilament ,in tumor tissue of ATMP treated group.The selectively antimetastatic effect of ATMP on LA-795 lung adenocarcinoma was also demonstrated.
Keywords:Aryltriazene methoxypyrimidine  Lewis lung carcinoma  LA-795 lung adenocarcinoma  Antimetastasis
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