血清CA19-9在胆道系统疾病中的临床意义

目的 评价CA19-9对胆道系统疾病的诊断价值.方法 回顾分析第二军医大学东方肝胆外科医院621例胆道疾病病例,测定血清CA19-9值,分析了血清CA19-9和临床诊断、血清胆红素水平、手术方式、病理及预后结果的关系.结果 在取37U/ml为阳性界值时,CA19-9具有最好的诊断准确率(93.9%),在胆道恶性肿瘤中的阳性率较良性疾病组增高有显著的意义;黄疸病例CA19-9阳性率较无黄疸对照组显著增高,而特异性降低.结论 血清CA19-9在胆道疾病的诊断、治疗监视及预后判断上具有较高的临床价值.

Clinical values of serum CA19-9 in diseases of biliary system

Objective To evaluate the clinical values of serum CA19-9 measurements in diseases Of biliary system.Methods Serum concentration of the CA19-9 antigen was determined in 621 patients with biliary diseases.Their serum bilirubin levels,operative managements,pathological factors and survivals were also analyzed.Results The highest effective percentage(93.9%)was observed at the CUt-off value of 37U/ml of serum CA19-9 level.Compared with benign disease group,it had a significant difference of the positive rate in malignant disease group of biliary system.A significant higher sensitivity rate and lower specificity rate were observed in patients with jaundice than those without jaundice.Conclusions The measurement of serum CA19-9 level has a important value for the diagnosis,operative management and prognosis of biliary system diseases.though a confident discrimination between benign and malignant jaundice could not be made on the basis of its elevation.