HLA and Behçet's disease in Northern Spain: Their lack of correlation with arthritis pattern |
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Authors: | J Sanchez Burson J Graña Gil M Rosales Rodriguez A Atanes Sandoval C Alonso Blanco F Galdo Fernandez |
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Institution: | (1) Rheumatology Unit., Hospital Juan Canalejo, La Coruña, Spain;(2) Preventive Medicine Unit, Hospital Juan Canalejo, La Coruña, Spain;(3) Immunology Unit., Hospital Juan Canalejo, La Coruña, Spain;(4) Sección Reumatologia, Hospital Juan Canalejo, Xubias de Arriba 84, 15006 La Coruña, Spain |
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Abstract: | Summary We have studied the characteristics of arthritis present in 32 patients with Behçet's disease (BD), and how this arthritis is related to the HLA markers class I. 84% of the patients presented arthritis, the most common being monoarthritis as the initial presentation, and oligoarthritis in subsequent episodes. In 63% of the cases, the development was in episodes of acute/subacute arthritis. We found statistically significant association between antigens B-5 and B-51, and the group with BD, with a relative risk of 3.89 and 4.71 respectively. The attempt to relate markers B-5, B-51 and B-27 to the presence of arthritis as well as to its manifestation and further development was not conclusive. |
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