Relationship of structural magnetic resonance imaging, magnetic resonance perfusion, and other disease factors to neuropsychological outcome in sickle cell disease |
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Authors: | Grueneich Royal Ris M Douglas Ball William Kalinyak Karen A Noll Robert Vannatta Kathy Wells Robert |
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Affiliation: | Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. |
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Abstract: | OBJECTIVE: To investigate the relationship between neuropsychological functioning and radiographic findings in children with sickle cell disease (SCD) with no history of clinical neurological events. METHODS: Thirty-one patients with SCD randomly selected from a regional treatment center underwent neuropsychological and disease severity assessments. Of these, 22 also had structural magnetic resonance imaging and magnetic resonance perfusion studies performed. RESULTS: Forty-five percent of the imaged subgroup showed imaging abnormalities that were found to be correlated with disease severity but not neuropsychological level of performance indices. A significant relationship, however, was found between imaging abnormalities and increased variability in neuropsychological performance. CONCLUSIONS: These results corroborate the high rate of rheologic and vascular pathology in SCD and underscore the importance of representing neuropsychological functioning in multiple ways. |
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Keywords: | sickle cell disease neuropsychological functioning imaging, disease severity. |
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