Vein Graft-Coated Vascular Stents: A Feasibility Study in a Canine Model |
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Authors: | Frank Schellhammer Jörg Haberstroh Ajay K. Wakhloo Eva Gottschalk Martin Schumacher |
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Affiliation: | (1) Department of Radiology, University of Cologne, Joseph-Stelzmann Strasse 9, D-50931 Cologne, Germany, DE;(2) Department of Neuroradiology, University of Freiburg, Breisacher Strasse 64, D-79108 Freiburg, Germany, DE;(3) Department of Surgical Research, University of Freiburg, Breisacher Strasse 64, D-79108 Freiburg, Germany, DE;(4) Department of Neurosurgery, State University of New York at Buffalo, School of Medicine and Biomedical Science, 3 Gates Circle, Buffalo, NY 14209, USA, US |
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Abstract: | Purpose: To evaluate different vein grafts for luminal coating of endovascular stents in normal canine arteries. Methods: Twenty-four tantalum Strecker stents were coated with either autologous (n= 10), denatured heterologous (n= 11), or denatured homologous vein grafts (n= 3). The carotid artery (n= 11) and the iliac artery (n= 13) were stented using a transfemoral approach. Angiograms were performed at days 0, 7, and 21, and months 3, 6, and 9. All grafts underwent histological examination. Results: Eight of 10 autologous vein grafts showed patency during the whole observation period of 9 months, without histological signs of inflammation. Denatured heterologous vein grafts revealed acute (n= 3), subacute (n= 5), or delayed (n= 3) vessel occlusion. Hyaloid transformation of the vein graft and lympho-plasmacellular formations were seen. Denatured homologous vein grafts showed acute vessel occlusion. Although significant inflammatory tissue response was seen, no host-versus-graft reaction was present. Conclusion: Autologous vein graft-coated stents showed good biocompatibility in canine arteries. Preparation was cumbersome and required surgical venae-sectio. Denatured vein grafts, however, were limited by inflammatory reactions. |
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Keywords: | : Arteries— Vein grafts— Interventional instrumentation— Stents, experimental— Animal studies |
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