| 氮酮对班布特罗透皮吸收的促渗作用研究 |
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| 引用本文： | 何威,陈海燕.氮酮对班布特罗透皮吸收的促渗作用研究[J].华西药学杂志,2004,19(1):39-41. |
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| 作者姓名： | 何威 陈海燕 |
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| 作者单位： | 中国医科大学附属第一医院,辽宁,沈阳,110001 |
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| 摘 要： | 目的 研究班布特罗的经皮渗透性，并考察不同浓度的氮酮对其的影响。方法以30％乙醇-水溶液为接受液，采用Valia-Chien水平扩散池进行大鼠离体皮肤的渗透实验。结果不同浓度的氮酮对班布特罗的促渗作用不同。结论 由t检验及SPSS曲线拟和的结果可知，氮酮对班布特罗透皮吸收的促进作用具有浓度依赖性，氮酮的最佳促渗浓度为5％，增渗比ER为8．58。
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| 关 键 词： | 氮酮 班布特罗 透皮吸收 促渗作用 |
| 文章编号： | 1006-0103(2004)01-0039-03 |
| 修稿时间： | 2003年5月1日 |
Permeation enhancing effect of Azone on the transdermal absorption of Bambuterol |
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| HE Wei,CHEN Hai-yan.Permeation enhancing effect of Azone on the transdermal absorption of Bambuterol[J].West China Journal of Pharmaceutical Sciences,2004,19(1):39-41. |
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| Authors: | HE Wei CHEN Hai-yan |
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| Abstract: | OBJECTIVE To study the transdermal permeability of Bambuterol,and to investigate the effect of Azone in different concentrations.METHODS To take 30% ethanol-water solution as acceptor,make the permeability test on the off-body skins of rats in Valia-Chien level diffusion chamber.RESULTS Different concentrations of Azone were responsible for the different influences on permeation enhancement of Bambuterol.CONCLUSION From the results of t test and curves fitting it was known that promotion of transdermal absorption of Bambuterol is dependent on the conentration of Azone,and the best concentration of Azone is 5% and ER is 8.58. |
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| Keywords: | Bambuterol Transdermal absorption Azone |
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