微波辐射联合阿霉素脂质体抗兔VX2肿瘤的效果

目的 探讨应用微波辐射联合阿霉素脂质体对兔VX2肝肿瘤的治疗作用。方法将肝脏已成功接种VX2肿瘤的新西兰大白兔随机分成4组，每组8只。A组为肝动脉注入阿霉素碘化油乳剂；B组为注入阿霉素脂质体碘化油乳剂；C组微波辐射联合栓塞阿霉素碘化油乳剂；D组微波辐射联合栓塞阿霉素脂质体碘化油乳剂；4组实验动物于介入术前1d、术后14d行CT肝脏扫描，测量肿瘤大小；术前1d、术后1d、7d行肝功能检查，在微波辐射前、辐射中、辐射后30min、1h测量呼吸频率、心率和体温。术后15d处死动物，全部实验动物均取肿瘤组织及周围组织作组织病理学检查。结果术前1d各组动物肿瘤体积、肝功能无明显统计学差异。术后14d平均肿瘤体积A组为（6．02士1．21）cm^3，B组为（5．74±1．43）cm^3，C组为（3．26±0．37）cm^3，D组为（1．89±0．14）cm^3。各组肝功能检测无明显差异；微波辐射后兔的生命体征稳定，病理学检查组织坏死程度为D组最为明显（P〈0．05）。结论经动脉途径应用阿霉素脂质体联合微波辐射抗兔VX2肝肿瘤效果明显，认为微波有助于提高阿霉素脂质体的抗肿瘤效果，联合治疗安全可行。

Therapeutic effect of microwave radiation combined with liposome Adriamycin transarterial embolization on liver VX2 tumor in rabbits

Objective To assess the therapeutic effect of microwave radiation combined with Adriamycin liposome on liver VX2 tumor in rabbits.Methods VX2 tumor pieces were successfully implanted into liver lobes of rabbits with liver tumors formation.All rabbits were divided randomly into 4 groups(each n=8).Group A underwent transcatheter arterial chemoembolization(TACE) with Adriamycin,group B were treated with Adriamycin liposome,group C were treated with microwave radiation combinate with Adriamycin,and group D were...