胃蛋白酶原C在胃癌及胃癌前疾病诊断中的意义

目的　探讨胃蛋白酶原C(PGC)在不同胃疾病中的动态表达情况并对其在胃癌前疾病及胃癌诊断中的价值作出评价。方法　采用免疫组织化学染色检测 4 2 4例胃黏膜标本中PGC的表达情况。结果　PGC抗原在 5 4例正常胃黏膜中全部阳性表达 (10 0 % ) ,在 12 4例胃癌中表达率显著下降 (2 4 % ) ,从浅表性胃炎或胃糜烂溃疡到萎缩性胃炎或异型增生再到胃癌 ,PGC阳性表达率依次逐渐下降 ,差异有非常显著意义 (P <0 0 1)。结论　PGC抗原的表达与胃黏膜细胞恶性程度呈负相关 ,与胃疾病的发生发展有良好的相关性。PGC抗原对于胃癌前疾病的诊断具有较高的灵敏度和特异度 ,对于癌前疾病的诊断 ,对胃癌筛查、早期诊断具有一定的参考价值。

Expression of pepsinogen C in gastric cancer and its precursor

OBJECTIVE: To investigate the dynamic expression of pepsinogen C (PGC) and its value in detection of precursor and gastric cancer. METHODS: Immunohistochemistry was used to examine the expression of PGC in 424 biopsy specimens of stomach mucosa collected by gastroscopy. RESULTS: The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100% and 2.4% in 124 cases of gastric cancer. The positive rate of PGC expression decreased in the order of superficial gastritis/gastric ulcer or erosion-->atrophic gastritis or gastric dysplasia-->gastric cancer (P < 0.01). CONCLUSION: The expression of PGC is negatively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. PGC has high sensitivity and specificity in diagnosis of precursor of gastric cancer and can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer.