妊娠期糖尿病孕妇血中肿瘤坏死因子α的变化

目的测定妊娠期糖尿病孕妇血清肿瘤坏死因子α(TNF-α)的水平,探讨TNF-α与妊娠期糖尿病的关系及在其发病中的作用。方法用ELISA方法测定33例妊娠期糖尿病孕妇及53例正常妊娠妇女空腹血清TNF-α水平(2组中分别分成4个妊娠阶段:孕25~28周、孕29~32周、孕33~36周、孕37~40周)。结果①正常妊娠、妊娠期糖尿病妇女血清TNF-α水平均随孕周的增长而升高;②妊娠期糖尿病孕妇4个阶段的血清TNF-α值分别为(7.92±1.68)ng/L、(9.46±2.40)ng/L、(10.87±2.38)ng/L和(11.51±4.55)ng/L。各项均显著高于同孕周正常妊娠妇女。结论正常妊娠妇女血清TNF-α水平随孕周增长而升高,妊娠期糖尿病孕妇血清TNF-α水平较正常妊娠妇女明显升高,推测TNF-α在妊娠期糖尿病的发病中有着重要作用。

A Study of Plasma Tumor Necrosis Factor-alpha in Patients with Gestational Diabetes Mellitus

Objective Plasma tumor necrosis factor-alpha(TNF-α) in prenatal women with gestational diabetes(GDM) was measured. Methods Fasting plasma TNF-α levels were determined with ELISA in 33 prenatal women with GDM and 53 cases of normal prenatal women, tests repeated for each group according gestational age in four stages of 25～28 weeks, 29～32 weeks, 33～36 weeks and 37～40 weeks. Results ① Plasma TNF-α levels in GDM and normal prenatal group rose as gestational age; ② Plasma TNF-α levels in GDM of four stages were (7.92±1.68)ng/L, (9.46±2.40)ng/L, (10.87±2.38)ng/L, and (11.51±4.55)ng/L respectively, all significantly increased than those in the same stage of normal prenatal group. Conclusion Plasma TNF-α levels in normal prenatal group rise with gestational age. Plasma TNF-α increases more significantly in GDM than in normal pregnancy. Plasma TNF-α is suggested to play an important role in the development of GDM.