| Immunohistochemical Analysis of EGF-R in Gastric Mucosa in Portal Hypertensive with Cirrhosis |
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| 引用本文： | 杨镇. Immunohistochemical Analysis of EGF-R in Gastric Mucosa in Portal Hypertensive with Cirrhosis[J]. 华中科技大学学报(医学英德文版), 1997, 17(4): 232-234. DOI: 10.1007/BF02895627 |
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| 作者姓名： | 杨镇 |
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| 作者单位： | Department of General Surgery，Tongji Medical Univesity，Wuhan 430030 |
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| 摘 要： | Inclinicalpractice,theupperdigestivetracthemorrhage(UDTH)causedbygastricmucosalesion(GML)duringportalhypertension(PHT)alreadyhasbeendrawingtheattentionofcliniciansandresearchers.AlotofstudiesshowedthatthedevelopmentofGMLduringPHTwasrelatedtomanyfactorsandtheimpairmentordestructionofdefensemechanismisoneofthemaincauses.ThecombinationofEGFandEGF-Rhasanobviousprotectiveeffectongastricmucosa,soitisimportanttostudythechangeincontentofEGF--RduringPHT.Inthisstudy,thePAPixnmunohistochemic…
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| 收稿时间： | 1997-01-03 |
Immunohistochemical analysis of EGF-R in gastric mucosa in portal hypertensive with cirrhosis |
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| C. Mba Mba,Yang Zhen. Immunohistochemical analysis of EGF-R in gastric mucosa in portal hypertensive with cirrhosis[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1997, 17(4): 232-234. DOI: 10.1007/BF02895627 |
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| Authors: | C. Mba Mba Yang Zhen |
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| Affiliation: | (1) Department of General Surgery, Tongji Medical University, 430030 Wuhan |
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| Abstract: | PAP Immunohistochemical technique was used to detect the expression and distribution of EGF-R in gastric mucosa in portal hypertensive pigs with cirrhosis. Our result showed that the EGF-R content in gastric mucosa of portal hypertensive pigs was significantly lower than that in control group. Microscopically, the portal hypertension (PHT) group imparted "feeble positivity" or "negative results" and the control group showed "strong positivity ".It was suggested that the decrease of EGF-R content in gastric mucosa weakened defense mechanism of gastric mucosa and increase its vulnerability. It is believed that the decreased EGF-R in gastric mucosa is ascribed to the lesions of gastric mucosa during PHT with cirrhosis. |
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| Keywords: | cirrhosis portal hypertension gastric mucosa EGF-R PAP immunohistochemistry |
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