血管紧张素转换酶基因多态性与重度子痫前期及肾功能损害的关系

目的 探讨血管紧张素转换酶(ACE)基因第16内含子插入/缺失(I/D)多态性与重度子痫前期和子病前期肾功能损害的关系.方法 采用聚合酶链反应(PCR)技术检测120例子痫前期(其中轻度67例,重度53例)和60例正常孕妇ACE基因I/D多态性.结果 重度子痫前期组分别与正常孕妇组和轻度子痫前期组比较,ACE基因型分布和等位基因频率均有显著差异(P＜0.01);子痫前期肾功能损害组与无肾功能损害组比较,ACE基因型分布有显著差异(P＜0.05).结论 ACE基因I/D多态性与子痫前期病情相关;ACE基因I/D多态性与子痫前期肾功能损害相关,DD基因型可能是子痫前期肾功能损害的危险因素.

Relationship between angiotensin converting enzyme gene polymorphism and severe preeclampsia and preeclampsia compli-cating renal dysfunction

Objective To investigate the relationship between the 16 intron insertion/deletion polymorphism of angiotensin converting enzyme(ACE) gene and severe preeclampsia and preeclampsia complicating renal dysfunction.Methods One hundred and twenty preeclamptic patients(including 67mild preeclampsia and 53severe preeclampsia) and 60 normal pregnant women were recruited.The insertion/deletion polymorphism of ACE gene was amplified by polymerase chain reaction(PCR).Results Compared severe preeclampsia group with normal pregnant group and mild preeclampsia group respectively,the distribution of ACE genotype and the frequency of allele were significantly different.There were significant differences in the distribution of ACE genotype when compared preeclampsia complicating renal dysfunction group with preeclampsia without renal dysfunction group.Conclusion The insertion/deletion polymorphism of ACE gene associated with the severity of preeclampsia.The insertion/deletion polymorphism of ACE gene associated with preeclampsia complicating renal dysfunction,the DD genotype was a high risk predict for preeclamptic renal dysfunction.