Blockade of IL-6 secretion pathway by the sesquiterpenoid atractylenolide III |
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Authors: | Kang Tae-Hee Han Na-Ra Kim Hyung-Min Jeong Hyun-Ja |
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Affiliation: | Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, 130-701, Republic of Korea. |
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Abstract: | Atractylenolide III (1) is the major bioactive component of Atractylodes lancea. The aim of this study was to analyze the effect on the regulation of interleukin (IL)-6 secretion pathway caused by 1. This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. In addition, 1 inhibited histamine release in stimulated HMC-1 cells. In stimulated HMC-1 cells, 1 suppressed activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB. In addition, 1 suppressed the activation of caspase-1 and the expression of receptor interacting protein-2. These results provide new insights that atractylenolide III (1) may control immunological reactions by regulating the cellular functions of IL-6 in mast cells. |
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