Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana |
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| Authors: | Songsiang Uraiwan Thongthoom Tula Boonyarat Chantana Yenjai Chavi |
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| Affiliation: | Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. |
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| Abstract: | Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells. |
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