Coeliac disease associated with Sjögren’s syndrome, renal tubular acidosis, primary biliary cirrhosis and autoimmune hyperthyroidism |
| |
Authors: | M. Fracchia, G. Galatola, F. Corradi, A. M. Dall Omo, L. Rovera, A. Pera, C. Vitale,M. T. Bertero |
| |
Affiliation: | Gastroenterology Unit, Mauriziano Umberto I Hospital, Institute for Cancer Research and Treatment--IRCC, 1-10060 Candiolo, Turin, Italy. ggalatola@mauriziano.it |
| |
Abstract: | Although coeliac disease may occur in patients affected by another immune-mediated disorder, its coexistence with multiple autoimmune diseases is not frequently described. We report here the case of a 45-year-old woman referred to our centre because of diarrhoea and weight loss, who had already received a diagnosis of primary biliary cirrhosis, Sj?gren's syndrome and renal tubular acidosis. Following the development of diarrhoea we established the diagnosis of coeliac disease, based on the presence of anti-endomysium antibodies and a compatible duodenal biopsy. Despite gluten withdrawal she went on to develop an autoimmune hyperthyroidism. The patient tested positive for HLA DRB1*03 and DQB1*02. The association is unlikely to be casual and may be explained by autoimmune mechanisms, genetic susceptibility and favouring environmental factors commonly shared by the diseases of our patient. |
| |
Keywords: | Autoimmune hyperthyroidism Coeliac disease Primary biliary cirrhosis Renal tubular acidosis Sjö gren’ s syndrome |
本文献已被 ScienceDirect 等数据库收录! |
|