| 油酸钠与紫外线及维生素C灭活水泡性口炎病毒的试验观察 |
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| 引用本文： | 刘蓉,沈德林,张文福,袁庆霞,钟儒渡. 油酸钠与紫外线及维生素C灭活水泡性口炎病毒的试验观察[J]. 中国消毒学杂志, 2001, 18(3): 135-140 |
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| 作者姓名： | 刘蓉 沈德林 张文福 袁庆霞 钟儒渡 |
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| 作者单位： | 军事医学科学院微生物流行病研究所 |
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| 基金项目： | 本课题由国家自然科学基金(39700127)资助 |
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| 摘 要： | 采用细胞感染法，对油酸钠、短波紫外线（ＵＶＣ）、维生素Ｃ（Ｖｉｔ Ｃ）灭活水泡性口炎病毒（ＶＳＶ）的作用进行了试验观察。结果，当油酸钠含量为２．０～３．０ ｍｇ／Ｌ，作用温度为４～３７℃时，随着油酸钠含量和温度的提高，ＶＳＶ滴度下降值由 １．１７ｌｇ ＴＣＩＤ５０增至４．５０ｌｇ ＴＣＩＤ５０；而作用时间在 ０．５～２ｈ之间变化，对病毒灭活效果无明显影响。ＵＶＣ照射剂量为 ２５ ５００～２０４ ０００ Ｊ／ｍ２，可使 ＶＳＶ下降 ２．３９～５．００个对数滴度，剂量－效应关系为指数函数关系。Ｖｉｔ Ｃ对 ＶＳＶ无明显灭活作用。
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| 关 键 词： | 血浆消毒 油酸钠 短波紫外线 维生素C 病毒灭活 水泡性口炎病毒 |
| 修稿时间： | 2000-09-15 |
EXPERIMENTAL OBSERVATION ON EFFICACY OF SODIUM OLEATE,ULTRAVIOLET RAYS AND VITAMIN CIN INACTIVATING VESICULAR STOMATITIS VIRUS |
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| Liu Rong Shen Delin Zhang Wenfu Yuan Qingxia Zhong Rubo. EXPERIMENTAL OBSERVATION ON EFFICACY OF SODIUM OLEATE,ULTRAVIOLET RAYS AND VITAMIN CIN INACTIVATING VESICULAR STOMATITIS VIRUS[J]. Chinese Journal of Disinfection, 2001, 18(3): 135-140 |
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| Authors: | Liu Rong Shen Delin Zhang Wenfu Yuan Qingxia Zhong Rubo |
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| Abstract: | The efficacy of sodium oleate, short-wave ultraviolet rays (UVC) and vitamin C (vit C) in inactivating vesicular stomatitis virus (VSV) was observed experimentally by means of cell infection method. The results indicated that when 2.0~3.0 mg/L of sodium oleate was used at the temperature of 4~37℃, reduction of VSV titer increased from 1.l7lg TCID50 to 4.50 lg TCID50 with increase in concentration of sodium oleate and the temperature, while varia- tion in exposure time from 0.5 to 2 h did not influence significantly the efficacy of inactivating the virus. UVC irradiation dose of 25 500~204 000 J/m2 could reduce the VSV titer by 2.39 ~5.00 lg and the dose-effect relation was exponential function relation. Vit C had no signifi- cant inactivating effect on VSV. |
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| Keywords: | plasma disinfection sodium oleate short-wave ultraviolet rays Vitamin C virus inactivation vesicular stomatitis virus |
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