硝酸银和滑石粉对兔胸膜的固定作用

目的：对比研究胸腔内注入硝酸银和滑石粉对兔胸膜的固定效果。 方法：分别采用0.5％硝酸银溶液和滑石粉匀浆（400 mg•kg^-1）对日本大耳白兔进行实验性胸膜固定，检测术后1及3 d胸液量、胸液中白细胞计数（WBC）、多形核中性粒细胞百分比(PMN%)和乳酸脱氢酶(LDH)含量。比较术后1、3、7、14及28 d硝酸银和滑石粉匀浆组胸膜黏连情况。 结果：硝酸银组术后1及3 d胸液量及WBC高于滑石粉组（P<0.001），且两组术后3 d兔胸液量及WBC均高于1 d(P<0.001)；两组术后1 d PMN%高于3 d(P<0.01)，硝酸银组术后3 d PMN%显著低于滑石粉组（P<0.001）。两组术后1 d LDH均高于3 d (P<0.001),而硝酸银组术后1和3 d胸液LDH含量高于滑石粉组（P<0.01）。术后胸膜黏连评分硝酸银组高于滑石粉组（P<0.05）。 结论：0.5％硝酸银溶液和滑石粉匀浆均能诱导实验性兔胸膜固定作用，硝酸银胸膜固定效果好于滑石粉。

Effects of pleurodesis with silver nitrate and talc in rabbits

Objective To study the effects of pleurodesis with the intrapleural injection of silver nitrate and talc in rabbits. Methods Intrapleural injection of 0.5% silver nitrate and talc slurry (400 mg·kg~ -1), respectively, were performed to Japanese white rabbits to produce pleurodesis, the pleural effusion volume, white blood cell (WBC) numbers, the percentage of polymorphonuclear neutrophil (PMN%) and the content of lactate dehydrogenase (LDH) of 1 and 3 d after intrapleural injection were examined. The pleural adhesion scores of 1,3,7,14,28 d after pleurodesis in silver nitrate group and talc group were compared. Results The pleural effusion volume and WBC in silver nitrate group were higher than those in talc group at 1 and 3 d after pleurodesis (P<0.001), effusion volume and WBC at 3 d in the two groups were higher than those at 1 d (P<0.001); PMN% in both groups at 1 d were higher than those at 3 d (P<0.01), but it was lower at 3 d in silver nitrate group compared with talc group (P<0.001); the LDH contents in both groups at 1 d were higher than those at 3 d (P<0.001), and the LDH contents at 1 and 3 d in silver nitrate group were higher than those in talc group (P<0.01). The pleural adhesion score in silver nitrate group was higher than that in talc group (P<0.05). Conclusion Both silver nitrate and talc slurry can produce pleurodesis in rabbit pleura, and the low concentration of silver nitrate is superior to talc slurry.