应力负荷下兔肩袖急性断裂重建后腱-骨修复动物模型建立及其修复过程中影像学评价

背景：目前尚无公认的动物模型可以作为应力负荷下肩袖损伤的相关研究标准的实验动物模型。目的：建立应力负荷下兔肩袖腱-骨急性断裂重建术后修复动物模型,并对其修复过程中进行影像学评价。方法：将新西兰白兔进行双侧肩关节行冈上肌腱离断术,并行冈上肌腱止点重建,术后随机分为应力负荷组与非应力负荷组。非应力负荷组正常笼养;应力负荷组于冈上肌腱重建术后第2周开始进行肩关节被动屈伸训练。分别于术后第2,4,8周训练结束后行肩关节MRI和超声检查。结果与结论：MRI检查结果显示：术后4和8周,T2WI相应力负荷组连接肌腱与骨组织低信号显示面积较非应力负荷组大。超声检查结果显示：术后4和8周,兔冈上肌腱止点重建处连续性回声,应力负荷组较非应力负荷组稍明显。结果提示,应力负荷下兔肩袖急性断裂术后腱-骨修复动物模型建立相对成功,一定的应力刺激能够促进肩袖腱-骨修复。

Construction of repair tendon-bone models in rabbits with postoperatibe acute rotator cuff rupture under stress and imaging evaluation during repairing

BACKGROUND：Though many kinds of animals were used as models in the experiment of rotator cuff injury under stress,yet there is no single can be as the standard experimental animal model.OBJECTIVE：To construct repair tendon-bone models of rabbits with acute rotator cuff rupture under stress and to evaluate the iconography in repairing.METHODS：New Zealand white rabbits were underwent transverse myotenotomy of supraspinatus tendon and tendon insertion site reconstruction.After surgery,all animals were randomly divided into the stress and non-stress groups.Rabbits in the non-stress group were raise in normal cage,and those in the stress group were trained passive flexion and extension at 2 weeks after the reconstruction of the supraspinatus tendon.MRI and ultrasound examination was performed at the 2,4 and 8 weeks after operation.RESULTS AND CONCLUSION：MRI test results：T2WI showed that the areas of the low signals of the tissues connected tendon and bone were larger and the signals of synovial fluid reduced more visible in stress group than in non-stress group at 4 and 8 weeks after operation.Ultrasound examination results：the continuous echoes appeared at the site of the rabbit supraspinatus tendon-bone in 2 groups,which showed more obvious in stress group than in non-stress group at 4 and 8 weeks after operation.The findings demonstrated that,repair tendon-bone models of rabbits with postoperatibe acute rotator cuff rupture under stress are successful constructed,and certain stress can promote repairing of the tendon-bone of rotator cuff.