血小板衍化生长因子在细胞增殖和组织修复中的作用及机制

背景：细胞增殖和组织修复是一个复杂的过程,这期间有大量生长因子参与,并且这些因子在发挥本身功效时,同时还相互影响和制约,从而更好地促进细胞增殖和组织修复。目的：总结血小板衍化生长因子在细胞增殖和组织修复愈合过程中发挥的作用及其机制。方法：检索PubMed数据库、EMbase数据库1960-01/2010-10期间相关文章,检索词为＂platelet-derived growth factor,cell proliferation,tissue repair＂。同时检索中国生物医学文献数据库、中文科技期刊全文数据库、中文学术期刊全文数据库2000-01/2010-10期间相关文章,检索词为＂血小板衍化生长因子＂。结果与结论：血小板衍化生长因子是一种重要的促细胞分裂剂,可刺激各种类型细胞的分裂增殖。血小板衍化生长因子及其受体存在于机体的多种组织细胞,当机体受到一定的刺激时,血小板衍化生长因子与其受体结合,发挥作用,因此许多研究发现,在外科手术后和损伤修复过程中常伴随有局部血小板衍化生长因子基因表达量的升高和受体的上调,被称为损伤修复因子。但是它的具体作用机制尚不太明确,对细胞组织的增殖修复的认识还处于起始、发展阶段,还有许多的问题需要去探索研究。

Role and mechanism of platelet-derived growth factor in cell proliferation and tissue repair

BACKGROUND：Cell proliferation and tissue repair is a complicated process,accompanied by participation of multiple growth factors,and these factors from a system in which they play their roles not in an independent,but interacting and inter-restricting manner.OBJECTIVE：To summarize the role and mechanism of platelet-derived growth factor （PDGF） in cell proliferation and tissue repair.METHODS：PubMed,EMbase,Chinese Biomedical Literature Database,CNKI,CAJ were retrieved by computer with keywords of ＂platelet-derived growth factor,cell proliferation,tissue repair＂.The language was limited for English and Chinese.RESULTS AND CONCLUSION：PDGF is one of the major mitogens and is responsible for proliferation and migration of various cells.PDGF and its receptors located in multiple tissues and cells,which combined with receptors and play its role when the body suffered certain stimulation.Thus,plenty of studies showed that the expression of PDGF gene was increased in the period of surgery or damage repair.The biological characteristics of PDGF have been recognized primarily.The specific mechanism of repair is not clarified and many problems need to be explored in further study.