骨骼肌重塑中的钙调神经磷酸酶信号转导通路

背景：骨骼肌重塑是骨骼肌对多种刺激因素所产生的形态结构与代谢机能的适应性变化。近几年关于钙调神经磷酸酶（CaN）/（NFATS）在骨骼肌重塑中的作用备受关注。目的：探讨钙调神经磷酸酶在骨骼肌从无氧转向有氧的代谢重塑、肌纤维类型转化以及在骨骼肌肥大过程中的信号转导作用。方法：由第一作者用计算机检索ISI Web of knowledge数据库（1998/2010）,检索词为＂calcineurin,skeletal muscle,hypertrophy,NFAT,myofiber type＂,语言设定为英文。从钙调神经磷酸酶信号系统在骨骼肌代谢、肌纤维类型转换和肌肉肥大中的作用方面进行总结,对其调节机制、肌肉重塑等方面进行介绍。结果与结论：共检索到186篇文章,按纳入和排除标准对文献进行筛选,共纳入33篇文章。结果表明CaN/NFATS信号激活有助于Ⅰ型肌纤维分化,提高线粒体有氧代谢能力,但骨骼肌对耐力运动的适应并不绝对依赖CaN。CaN/NFATS转导通路有可能通过转录激活utrophin A来调控骨骼肌的肥大反应。由此可知钙调神经磷酸酶参与骨骼肌代谢、纤维转化和肥大的重塑过程,调节骨骼肌对刺激产生适应性应答反应。

Effect of Calcineurin transduction pathway on skeletal muscle remodeling

BACKGROUND：Skeletal muscle remodeling is an adaptive change of morphological structure and metabolic function to response to multiple stimuli.In the past years,the role of Calcineurin （CaN）/nuclear factor of activated T cells （NFAT） signaling has aroused increasing attention in skeletal muscle remodeling.OBJECTIVE：To summarize and discuss the functions of CaN signaling transduction in metabolic remodeling from anaerobic metabolism to aerobic metabolism,myofiber type conversion,and skeletal muscle hypertrophy.METHODS：A compute-based online search was performed by the first author ISI Web of knowledge database （1998/2010） with key words were ＂calcineurin,skeletal muscle,hypertrophy,NFAT,muscle fiber type＂ in English.The functions of CaN signaling transduction in metabolic remodeling were introduced from anaerobic metabolism to aerobic metabolism,myofiber type conversion,and skeletal muscle hypertrophy.RESULTS AND CONCLUSION：A total of 186 papers had been searched and 33 papers were chosen.The result shows that the activation of CaN/NFAT signaling contributes to the differentiation of myofiber type I and the improvement of aerobic metabolism and endurance,but not only CaN can improve the endurance.CaN/NFAT signaling transduction pathway may regulate skeletal muscle hypertrophy by the activation of utrophin A.Accordingly,calcineurin plays a role in skeletal muscle metabolism,fiber transformation,and hypertrophic remodeling,and modulates adaptive response to stimuli.