组织工程化肌腱在肌腱修复过程中的作用

目的：综述肌腱组织工程在肌腱修复过程中的应用进展。方法：应用计算机检索1993-01/2009-10PubMed数据库及维普数据库有关肌腱组织工程研究进展、肌腱支架材料生物力学分析、生物材料在肌腱组织工程中应用及组织工程技术在修复肌腱缺损临床应用方面的相关文献,英文检索词为＂tendontransplantation,tissue engineering,biologicalmaterial,cellstent＂,中文检索词为＂肌腱移植,组织工程,生物材料,细胞支架＂。检索文献量总计132篇。结果：目前组织工程化肌腱的研究已经取得了显著的成果,但要真正应用于临床,大批量生产,仍存在一些问题。诸如最适的种子细胞来源、理想的支架材料、最佳的培养条件以及植入体内的检测方法等,在组织工程真正成为一种治疗肌腱缺损和功能重建的选择之前,这些问题都是有待进一步研究和解决的。结论：要真正实现体外预制有生命的种植体完全替代人体组织、器官功能,尚面临着许多挑战。

Role of tissue engineered tendon in tendon repair

OBJECTIVE： To review the research progress of tendon tissue engineering in the process of tendon repair. METHODS： A computer-based search of PubMed database and VIP database from January 1993 to October 2009 was performed for articles regarding the tendon tissue engineering, bio-mechanical analysis of tendon scaffolds, biomaterials’ application in tendon tissue engineering and tissue engineering technology in the clinical application of tendon defect repair. English key words are ＂tendon transplantation, tissue engineering, biological material, cell stent＂, Chinese key words are ＂tendon transplantation, tissue engineering, biomaterials, cell scaffold＂. A total of 132 literatures were screened out. RESULTS： At present, the tendon tissue engineering research has achieved remarkable results, but there are still some problems for clinical practice and mass production. Many issues need to be further studied and solved prior to tissue engineering truly becomes a treatment of tendon defect and functional reconstruction, such as the best source of seed cells, the ideal scaffold material, the best culture conditions and detection methods of implantation in vivo. CONCLUSION： Truly realizing the replacement of human tissues and organs with the in vitro prefabricated living implant, still faces many challenges.