| 自制CPC纳米复合材料溶血试验和短期全身毒性试验的研究 |
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| 引用本文： | 张冬华,车向新,李卫东. 自制CPC纳米复合材料溶血试验和短期全身毒性试验的研究[J]. 南昌大学学报(医学版), 2010, 50(5) |
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| 作者姓名： | 张冬华 车向新 李卫东 |
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| 作者单位： | 张冬华,ZHANG Dong-hua(南昌大学研究生院医学部2007级,南昌,330006);车向新,李卫东,CHE Xiang-xin,LI Wei-dong(九江学院基础学院江西省高校系统生物学临床应用重点实验室,江西,九江,332000) |
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| 摘 要： | 目的 依据相关标准初步评价自制CPC纳米复合材料的生物相容性,为材料的最终临床应用提供实验依据.方法 根据YY/T 0127.1-93和YY/T 0244-1996标准,用体外溶血试验及经口途径短期全身急性毒性试验评价自制CPC纳米复合材料的安全性.结果 自制材料浸提液对健康人血红细胞溶血率为0.1%(＜5%),无溶血现象;经口途径短期全身急性毒性试验的大鼠每周食物利用率及体质量相对增长率与对照组之间均差异无统计学意义(P>0.05),心、肾、肝等重要脏器肉眼观察无异常改变,其组织切片未出现病理学变化.结论 自制CPC纳米复合材料生物相容性符合国内的体内植入物的生物学评价标准,具有良好的生物相容性.
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| 关 键 词： | 磷酸钙骨水泥 溶血试验 短期全身毒性试验 生物相容性 |
Hemolysis Test and Short-term Systemic Toxicity of CPC Nanocomposite Materials |
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| ZHANG Dong-hua,CHE Xiang-xin,LI Wei-dong. Hemolysis Test and Short-term Systemic Toxicity of CPC Nanocomposite Materials[J]. Journal of Nanchang University(Medical Science), 2010, 50(5) |
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| Authors: | ZHANG Dong-hua CHE Xiang-xin LI Wei-dong |
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| Affiliation: | ZHANG Dong-hua1,CHE Xiang-xin2,LI Wei-dong2(1.2007 Grade of Medical Department of Graduate School,Nanchang University,Nanchang 330006,China,2.Key Laboratory of Jiangxi University for the Systems BiologyClinical Application,Jiujiang University,Jiujiang 332000,China) |
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| Abstract: | Objective To evaluate the biocompatibility of self-CPC nanocomposite materials according to the relevant standards,and to provide the experimental basis for clinical application of the materials.Methods According to YY / T 0127.1-93 and YY/T 0244-1996 standards,self-CPC nanocomposites security was assessed by hemolysis test in vitro and short-term systemic acute toxicity test by oral means.Results The extracts of the self-made materials were considered to be no hemolysis and the healthy red blood cell hemol... |
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| Keywords: | calcium phosphate cement hemolysis test in vitro short-term systemic acutetoxicity test biocompatibility |
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