| 曲美他嗪对不稳定性心绞痛患者血管内皮功能的保护作用 |
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| 引用本文： | 陈斐,陈彤彦,顾国宝. 曲美他嗪对不稳定性心绞痛患者血管内皮功能的保护作用[J]. 中国民族民间医药杂志, 2009, 18(6) |
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| 作者姓名： | 陈斐 陈彤彦 顾国宝 |
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| 作者单位： | [1]上海市闸北区中心医院心内科,上海200070 [2]上海市闸北区中心医院超声科,上海200070 [3]上海市闸北区中心医院检验科,上海200070 |
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| 摘 要： | 目的：观察曲美他嗪对不稳定性劳力型心绞痛患者血管内皮功能的保护作用，并探讨其可能原因。方法：61例不稳定性劳力型心绞痛患者，被随机分为常规治疗组（30例）和曲美他嗪组（31例），常规治疗组给予扩冠、抗凝、调血脂等治疗，曲美他嗪组在常规治疗基础上加用曲美他嚷20rag，3次／d，服用8周。结果：血浆hs—CRP：治疗前曲美他嗪组和常规治疗组均较健康对照组升高；治疗后曲美他嗪组与常规治疗组均显著降低，曲美他嗪组较常规治疗组降低显著（P〈0．05）。治疗前FMD：曲美他嗪组和常规治疗组均较健康对照组明显降低；治疗后曲美他嗪组与常规治疗组均显著升高，曲美他嗪组较常规治疗组升高更加显著（P〈0．05）。结论：曲美他嗪在不稳定心绞痛患者治疗中能减轻血管炎症反应，改善血管内皮功能的作用。
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| 关 键 词： | 曲美他嗪 不稳定型劳力性心绞痛 hs—CRP 血管内皮功能 |
Protection effect of trimetazidine therapy on vascular endothelial function in patients with unstable angina pectoris |
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| CHEN Fei CHEN Tongyan GU Guobao. Protection effect of trimetazidine therapy on vascular endothelial function in patients with unstable angina pectoris[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2009, 18(6) |
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| Authors: | CHEN Fei CHEN Tongyan GU Guobao |
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| Affiliation: | 1.Department of Cardioology;2.Department of Ultrasound;3.Department of Clinical laboratory;in Shanghai Zhabei District Central Hospitai;Shanghai;200070;China |
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| Abstract: | Objective:To observe protection effect of trimetazidine therapy on vascular endothelial function in patients with unstable angina pectoris(UAP),and study its mechanism.Method:The 61UAP patients were randomly divided into routine therapy group and trimetazidine group.The routine therapy group was received routine therapy fpr UAP.The trimetazidine 20 mg,3 times daily were given to each cases of trimetazidine group besides routine therapy.The plasma highsensitive C-reactive protein(hs-CRP) and brachial artery ... |
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| Keywords: | Trimetazidine ?unstable angina pectoris hs-CRP vascular endothelial function |
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