p53基因codon72多态性与亚洲人群前列腺癌发病风险的Meta分析

目的 利用Meta分析的方法系统评价p53基因codon72多态性与亚洲人群前列腺癌发病风险的关系.方法 检索PubMed、Medline、Ovid、万方和CNKI数据库,筛查p53基因codon72多态性位点与亚洲人群前列腺癌易感性关联的病例-对照研究.采用Stata 12.0软件对获得的各项研究数据进行统计分析,并评估数据的可靠性和统计文献的发表偏倚等.结果 Meta分析显示,p53基因codon72多态性与亚洲人群前列腺癌发病风险无明显相关性.对对照组来源进行亚组分析结果显示,基于医院来源的亚组,codon72多态性在Pvs.AOR=0.680,95％CI(0.546,0.847),P=0.001]、PP vs.AAOR=0.409,95％CI(0.260,0.645),P=0.000]、PA+PP vs.AAOR=0.513,95％CI(0.350,0.749),P=0.001]等模型中均能显著降低亚洲人群的前列腺癌易感性.然而,在对照组来源基于普通人群的亚组中,codon72多态性位点在PA vs.AAOR=1.664,95％CI(1.272,2.177),P=0.000]和PA+PP vs.AAOR=1.314,95％CI(1.020,1.693),P=0.003 6]的基因型中却增加了亚洲人群前列腺癌发生的危险性.根据是否符合HWE平衡进行了亚组分析,结果发现,在不符合HWE平衡的亚组中,p53基因codon72多态性在PP vs.AAOR=0.251,95％CI(0.135,0.467),P=0.000]和PA+PP vs.AAOR=0.564,95％CI(0.330,0.964),P=0.036]的基因型中是降低亚洲人群前列腺癌易感性的一个保护因素.结论 p53基因codon72多态性与亚洲人群前列腺癌易感性无关.

A meta analysis of p53 gene codon72 polymorphism and onset risk of prostate cancer among Asian population

Objective To systematically evaluate the relationship between p53 gene codon72 polymorphism and onset risk of prostate cancer (PCa) among Asian population by meta-analysis.Methods The databases of PubMed,Medline,Ovid,Wanfang and CNKI were retrieved for screening the case control trials on the relationship between p53 gene codon72 polymorphism and onset risk of PCa among Asian population.The obtained data were statistically analyzed by using the Stata 12.0 software,moreover the data reliability and publication bias of statistical literature were evaluated.Results The meta analysis showed that the p53 gene codon72 polymorphism had no obvious correlation with PCa onset risk in Asian population.The subgroup analysis results on the control source showed the coden72 polymorphism in P vs.A,PP vs.AA,PA+PP vs.AA models based on the hospital source subgroup could significantly decrease the Pca susceptibility among Asian populationP vs.A:OR =0.680,95 ％ CI(0.546,0.847),P=0.001;PP vs.AA:OR=0.409,95％CI(0.260,0.645),P=0.000;PA+PP vs.AA:OR=0.513,95％CI(0.350,0.749),P=0.001],whereas the codon 72 polymorphism in PA vs.AA and PA+PP vs.AA genotypes in the control source subgroup based on the common population increased the PCa onset risk among Asian population PA vs.AA:OR=1.664,95 ％CI(1.272,2.177),P=0.000;PA+ PP vs.AA:OR =1.314,95 ％ CI(1.020,1.693),P =0.003 6].The subgroup analysis was conducted according to whether conforming to the HWE equilibrium,the results showed p53 gene codon 72 polymorphosm was a protective factor for decreasing PCasusceptibility among Asian population in the subgroup unconforming to the HWE equilibrium PP vs.AA:OR=0.251,95％CI(0.135,0.467),P=0.000;PA+PPvs.AA:OR=0.564,95％CI=(0.330,0.964),P=0.036].Conclusion p53 gene codon72 polymorphism has no relation with PCa susceptibility among Asian population.