碘超足量地区吸烟与甲状腺关系的研究

目的 探讨碘超足量地区中、老年人群不同吸烟状态与甲状腺的关系及其他相关影响因素.方法 于2011年随机抽取贵阳市40～80岁常驻居民共10 140例,进行问卷调查、体格、生化及甲状腺B超检查.应用回归分析比较不同吸烟状态与甲状腺体积、促甲状腺素(TSH)、甲状腺肿和甲状腺结节之间的关系及其他相关因素.结果 经排除,共纳入研究对象6 122例;经分析,曾经吸烟、目前吸烟及男性与TSH呈负相关(P＜0.05);目前吸烟、男性、体质量指数与甲状腺体积呈正相关(P＜0.05);吸烟与甲状腺肿、甲状腺结节的患病率均无关(P＞0.05),年龄、女性是甲状腺结节的危险因素(P＜0.05).结论 吸烟可影响促甲状腺素水平,目前吸烟者有着较大的甲状腺体积,吸烟与甲状腺肿、甲状腺结节的患病率均无关.

Study on relationship between smoking and thyroid in iodine excessive area

Objective To investigate the relationship between different smoking status with thyroid gland and its other related influence factors among the middle age and elderly population in iodine excessive area.Methods A total of 10 140 permanent residents aged 40-80 years old in Guiyang City during 2011 were randomly sampled for conducting the questionnaire survey,physical examination,biochemical detection and B-type ultrasonic examination of thyroid.The regression analysis was used to compare the relationship between different smoking status with thyroid volume,thyroid stimulating hormone(TSH),thyroid goiter and thyroid nodules as well as other related factors.Results After exclusion,a total of 6 122 research subjects were included in the study;the analysis results showed that once smoking group,current smoking and male were negatively correlated with TSH (P＜0.05);current smoking,male and body mass index were positively correlated with thyroid volume(P＜0.01);smoking had no relation with the prevalence rate of goiter and thyroid nodules(P＞0.05),and the age and female were the risk factors for thyroid nodules (P＜ 0.05).Conclusion Smoking can affect the TSH level,current smokers have a larger thyroid volume,and smoking has no relation with the prevalence rate of goiter and thyroid nodules.