微创清除颅内血肿降低病灶周围组织谷氨酸水平及BBB通透性

目的 探讨微创颅内血肿清除对降低病灶周围脑组织谷氨酸(Glu)水平、血脑屏障(BBB)通透性及脑水肿的影响.方法 将30只体质量2.80～3.40 kg的家兔制作自发性脑出血(ICH)模型,模型制作成功后,分成对照组(MC组)和微创组(MI组),MI组于造模后6h内通过立体定向仪行微创颅内血肿清除术,于术后1、3、7d提取脑组织,检测血肿周围脑组织Glu水平、BBB通透性及脑含水量,并与对照组进行比较分析.结果 MI组在术后1、3、7d血肿周围脑组织Glu水平、BBB通透性及脑含水量均低于MC组,差异有统计学意义(P＜0.05).结论 微创技术清除颅内血肿有利于降低血肿周围Glu水平、BBB透性及脑含水量.

Minimally invasive surgery for removing intracranial hematoma and decreasing perihematomal glutamate content and permeability of blood-brain barrier

Objective To investigate the effects of minimally invasive intracranial hematoma clearance on the perihematomal glutamate(Glu) level,permeability of blood-brain barrier(BBB) and brain edema.Methods Thirty rabbits with body weight of 2.80-3.40 kg were used to established the model of spontaneous intracerebral hemorrhage(ICH) and randomly divided into the minimally invasive group(MI) and control group(MC) after the model was prepared successfully.The MI group underwent minimally invasive procedures for removing intracranial hematoma by stereotactic instrument within 6 h after establishing the ICH model.The brain tissue was extracted on postoperative 1,3,7 d,and the perihematomal brain tissues were taken to detect the Glu level,BBB permeability and water content of brain tissue,which were compared with those in the control group.Results The Glu level,BBB permeability and brain water content on 1,3,7 d in the MI group were lower than those in the MC group,and the differences were statistically significant(P＜0.05).Conclusion The minimally invasive surgery for removing intracranial hematoma is helpful to reduce perihematoma Glu level,BBB permeability and brain water content.