缺血性脑卒中患者颈动脉斑块性质与Cat S及Cys C的相关性

目的 探讨缺血性脑卒中患者血清组织蛋白酶S(Cat S)与胱抑素C(Cys C)表达水平与颈动脉斑块性质的关系.方法 336例动脉粥样硬化性脑梗死患者,根据颈部血管超声分为稳定斑块组与不稳定斑块组;同期114例健康体检者为对照组.所有入组者空腹采血检测血清Cat S及Cys C.结果 两组患者血清Cat S、Cys C及二者的比值(Cat S/Cys C)差异均有统计学意义(P＜0.05);且脑梗死患者不稳定斑块组血清Cat S较稳定斑块组增高,而血清Cys C水平较稳定斑块组降低,血清CatS分别为(75.33±15.44)、(60.13±18.54)pg/mL,血清Cys C分别为(0.72±0.63)、(0.92±0.54) mg/L,Cat S/Cys C分别为103.67±2.53、64.63±9.23,两组比较,差异均有统计学意义(P＜0.05);经Spearman相关分析,血清Cat S水平及Cat S/Cys C与缺血性脑卒中患者颈动脉不稳定斑块的存在呈明显的正相关性(r=0.498,P＜0.05;r=0.753,P＜0.01);而血清Cys C水平呈负相关性(r=-0.213,P＜0.05).结论 血清Cat S/Cys C水平与缺血性脑卒中患者颈动脉斑块性质存在一定的相关性,有可能成为预测颈动脉斑块性质的血清学指标.

Correlation between carotid arterial plaque property with Cat S and Cys C in patients with ischemic stroke

Objective To investigate the relationship between serum cathepsin S (Cat S) and cystatin C(Cys C) expression levels with carotid arterial plaque property in the patients with ischemic stroke(IS).Methods A total of 336 cases of atherosclerotic cerebral infarction were divided into the stable plaque and unstable plaque group according to the carotid arterial ultrasound.Contemporaneous 114 individuals undergoing healthy physical examination served as the control group.Fasting blood was collected from all subjects entering the groups for detecting serum Cat S and Cys C.Results The serum Cat S and Cys C levels and Cat S/Cys C ratio (Cat S/Cys C) had statistically significant difference between the two groups (P＜0.05),moreover the Cat S level in the unstable plaque group of the patients with cerebral infarction was increased compared with that in the stable plaque group,while serum Cys C level was decreased compared with that in the stable plaque group (P＜0.05).The Cat S levels were (75.34-±-15.45)pg/mL and (60.12±18.53)pg/mL and the Cys C levels were (0.73±0.62)mg/L and (0.93±0.53)mg/L,the Cat S/Cys C ratios were (103.68±2.52) and (64.64± 9.24) respectively,the difference between the two groups had statistical significance (P＜0.05).The Spearman correlation analysis showed that the serum Cat S level and Cat S/Cys C ratio had obviously positive correlation with carotid arterial unstable plaque (r=0.498,P＜0.05;r=0.753,P＜0.01);while the level of serum Cys C was negatively correlated with the unstable plaque (r=-0.213,P＜0.05).Conclusion Serum Cat S/Cys C level has a certain correlation with carotid arterial plaque property in ischemic stroke patients,which may become the serological indicators for predicting carotid arterial plaque.