胃微生态与胃癌的研究进展

胃微生态平衡是人体健康的重要前提,幽门螺杆菌(Helicobacter pylori,Hp)是目前已发现的与胃癌相关的关键病原体之一,普遍存在于人胃黏膜上皮。Hp感染可引起胃内其他菌群的改变,还可引起长期慢性的胃黏膜损伤,导致一系列胃黏膜上皮恶性进展和胃癌的发生。本文就胃微生态与Hp感染的关系、Hp感染在胃癌发生中的作用、胃内其他菌群在胃癌发生中的作用及微生态制剂在胃癌治疗的作用进行综述。进一步揭示Hp感染对胃微生态平衡的影响,胃微生态平衡和Hp感染在胃癌发生发展中的作用及微生态制剂在胃癌治疗中的意义。

Research progress of gastric microecology and gastric cancer

Gastric microecology is the critical premise of human health. Helicobacter pylori (Hp) is one of the pivotal pathogens related to gastric cancer, and Hp is commonly present in human gastric epithelial cells. Hp infection can give rise to changes of other bacterial flora in the stomach and long-term chronic gastric mucosal injuries, thus lead to a series of malignant progression of gastric mucosa, and even gastric cancer. In this review, we summarize the relationship of gastric microecology and Hp infection, the role of Hp infection and other gastric flora in gastric carcinogenesis, and the effect of microecologics in gastric cancer treatment. This review aims to further reveal the influence of Hp infection in gastric microecology, the role of gastric microecology and Hp infection in gastric carcinogenesis, and the significance of microecologics in the treatment of gastric cancer.