戊型肝炎肝衰竭患者的血生化指标及血清IL-22表达水平研究

目的研究由HEV感染引起的肝衰竭(hepatic failure,HF)患者肝功能指标特征及血清IL-22水平。方法回顾性分析132例戊型肝炎(戊肝)HF病例资料,按照是否有HBV感染分为混合感染HF组和单纯戊肝HF组,比较2组肝功指标、IL-22、IL-6以及IFN-γ水平。以普通戊肝组和健康体检组作对照,比较4组IL-22、IL-6及IFN-γ水平。结果混合感染HF组ALT、TBIL水平高于单纯戊肝HF组(P均0.05),PA水平低于单纯戊肝HF组(P0.05)。在IL-22水平方面,戊肝患者均高于健康对照者,混合感染HF组最高,普通戊肝组最低。在IL-6水平方面,HF患者均高于健康对照者,且混合感染HF组最高(P均0.05),但是普通戊肝组与健康对照组差异无统计学意义。4组IFN-γ差异无统计学意义。结论与单纯戊肝HF患者相比,混合感染HF组肝功能损害程度更严重。戊肝患者IL-22、IL-6水平升高,发生HF时明显升高,合并HBV感染时更高。

Blood biochemical indexes and serum IL-22 level in patients with hepatitis E virus-induced hepatic failure

Objective To study liver function index and serum IL-22 levels in patients with hepatic failure (HF) induced by HBV. Methods A total of 132 HF patients were analyzed retrospectively. According to the presence of HBV co-infection, the involved patients were divided into co-infected HF group and simple infected HF group. Liver function indexes and IL-22, IL-6 and IFN-γ levels in 2 groups were compared. In addition, normal infection group and healthy examination group were defined, IL-22, IL-6 and IFN-γ levels among 4 groups were also compared. Results ALT and TBIL levels in the co-infected HF group were significantly higher than these in simple infected HF group (P < 0.05), while PTA level was lower (P < 0.05). IL-22 levels in the patients with HEV infection were higher than that in healthy controls, the co-infected HF patients showed the highest levels, and simple infected patients showed the lowest levels. IL-6 levels in the HF patients were higher than that in healthy controls (P < 0.05), and the HF patients with co-infection showed the highest level, but no significant difference was found between simple infection and health control groups. There were no significant differences in IFN-γ levels among 4 groups. Conclusions Compared with HF patients, the HF patients with HBV co-infection exhibit more severe liver dysfunction. IL-22 and IL-6 levels are higher in the infected patients, obviously increased in HF patients and extremely increased in HF patients with HBV co-infection.