NT-proBNP与炎症因子在先兆子痫的诊疗价值及临床意义

目的 探讨NT-proBNP与炎症因子对先兆子痫的诊疗价值及临床意义.方法 选取该院2015年2月至2016年2月正常妊娠孕妇81例为A组,轻度先兆子痫患者81例为B组,重度先兆子痫患者81例为C组,行NT-proBNP与炎症因子检测.比较各组NT-proBNP与炎症因子差异,分析NT-proBNP、炎症因子与先兆子痫的相关性.结果 治疗前NT-proBNP、C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子α(TNF-α)比较,从高到低为C、B、A组(P＜0.05).治疗后,B组与C组NT-proBNP、CRP、IL-6、TNF-α降低(P＜0.05).治疗后NT-proBNP、CRP、IL-6、TNF-α比较,从高到低为C、B、A组(P＜0.05).NT-proBNP、CRP、1L-6、TNF-α与先兆子痫呈正相关(r=0.569、0.602、0.418、0.427,P=0.000).并发症发生率比较,从高到低为C、B、A组(P＜0.05).结论 先兆子痫患者NT-proBNP与炎症因子有升高趋势,可将其作为先兆子痈评价的有效指标.

Diagnostic value and clinical significance of NT-proBNP and inflammatory factors in pre-eclampsia

Objective To investigate the diagnostic value and clinical significance of NT-proBNP and inflammatory factors in pre-eclampsia.Methods A total of 81 normal pregnant women was selected in the hospital from February 2015 to February 2016 as group A,81 pregnant women with mild pre-eclampsia as group B and 81 pregnant women with severe pre-eclampsia as group C.NT-proBNP and inflammatory factors detection were performed.Differences of NT-proBNP and inflammatory factors in both groups were compared.Correlation between NT-proBNP,inflammatory factors and pre-eclampsia was analyzed.Results The levels of NT-proBNP,C-reactive protein(CRP),interleukin-6 and tumor necrosis factor-α(TNF-α) were measured before and after treatment.Before treatment,with regard to those indicators,the three groups ranked in descending order were C,B,A group(P＜0.05).After treatment,with regard to those indicators which were decreased in group B and group C(P＜0.05),the three groups ranked in descending order were C,B,A group (P ＜ 0.05).Those indicators were positively correlated with pre-eelampsia (r =0.569,0.602,0.418,0.427,P=0.000).As for incidence of complications,the three groups ranked from high to low were C,B,A group (P＜0.05).Conclusion NT-proBNP and inflammatory factors have a tendency to increase in patients with pre-eclampsia,which can be used as effective indexes for the evaluation of pre-eclampsia.