女性不孕症患者细菌性阴道病与支原体感染状况分析

目的 调查女性不孕症患者细菌性阴道病(BV)与支原体感染状况.方法 收集2013年6-12月在海南省人民医院妇科门诊就诊的541例女性不孕症患者分泌物标本,同时做BV检测和支原体培养及药敏试验.结果 支原体培养阳性率为44.5％(241/541),其中解脲支原体(UU)检出率最高,有223例感染,阳性率41.2％,人型支原体(Mh)感染5例,阳性率0.9％,UU+Mh混合阳性13例,阳性率2.4％.BV感染325例,阳性率为60.1％(325/541).在241例支原体阳性患者中BV阳性检出率为70.1％(169/241),300例支原体阴性患者中BV阳性检出率为52.0％(156/300),支原体阳性组与支原体阴性组BV的检出率比较,差异有统计学意义(P＜0.05).氟诺喹类的氧氟沙星耐药率最高,敏感率只有7.1％.交沙霉素耐药率最低,占3.7％.结论 女性不孕症患者与BV和支原体感染密切相关,应加强BV及支原体普查,做到早诊断,早治疗.支原体药敏试验显示,强力霉素、美满霉素、交沙霉素敏感率最高,可以作为临床医生首选药物.

Analysis on bacterial vaginosis and mycoplasma infection status in female patients with infertility

Objective To investigate the bacterial vaginosis(BV) and mycoplasma infection status in female patients with infertility.Methods The vaginal discharge samples were collected from 541 female patients with infertility in the gynecological department of the Hainan Provincial People's Hospital from June to December 2013.The BV detection,mycoplasma culture and drug susceptibility test were simultaneously conducted.Results The mycoplasma culture positive rate was 44.5％ (241/541),in which ureaplasma mycoplasma (UU) had the highest detection rate,there were 223 cases ofinfection with the positive rate of 41.2 ％,there were 5 cases of mycoplasma hominis(Mh) infection with the positive rate of 0.9 ％,13 cases were UU + Mh mixed positive with the positive rate of 2.4％.BV infection was in 325 cases with the positive rate of 60.1％ (325/541).Among 241 cases of mycoplasma positive,the BV detection rate was 70.1％ (169/241),while among 300 cases of mycoplasma negative,the BV detection rate was 52.0％ (156/300),the BV detection rate had statistical difference between the mycoplasma positive group and mycoplasma negative group,the difference was statistically significant (P＜0.05).Ofloxacin in fluoroquinolones had the highest drug resistance,the sensitivity was only 7.1％.Josamycin had the lowest drug resistance,accounting for 3.7 ％.Conclusion The female patients with infertility is closely correlated with BV and mycoplasma infection.Therefore BV and mycoplasma census should be strengthened to achieve early diagnosis and early treatment.Mycoplasma drug susceptibility test shows that doxycycline,minocycline and josamycin have the highest sensitivity,which can be used as the first selection drugs for clinical doctor.