癫痫和抗癫痫药对事件相关电位N270的影响

目的 探讨癫痫患者事件相关电位N270的特征及其反映患者认知功能的价值。方法 35侧癫痫患者根据服药情况分为卡马西平组、丙戊酸钠组和未用药组，另设健康志愿者作为对照组。所有受试者均接受简易智力量表问卷测试．同时记录事件相关电位。结果 3组患者的N270差异曲线峰潜伏期长于对照组，波幅低于对照组，其中丙戊酸钠组患者的峰波幅低于其他3组（P〈0．05）。患者组P300峰波幅低于对照组，丙戊酸钠组的波幅低于其他3组（P〈0．05）。结论 癫痫患者存在认知功能损害；抗癫痫药丙戊酸钠对癫痫患者处理冲突能力的损害较卡马西平明显；N270检测癫痫患者早期认知损害的敏感度高于P300。

Effect of Epilepsy and Anti-epileptic Drug on Event-related Potential N270

ObjectiveTo investigate the characteristics of event-related potential (ERP) N270 and the value of ERP N270 to detect the cognitive function in patients with epilepsy.MethodsThirty-five epileptics were divided into carbamazepine (CBZ) group (n=10), valproate (VPA) group (n=10) and no treatment group (n=15) according to drugs they took, and other 10 healthy subjects were selected as the control group. All subjects were evaluated by Mini-Mental State Examination (MMSE), and ERP was recorded at same time.ResultsAll patients in three groups showed a delayed and smaller N270 than the control group ( P<0.01). VPA group had the lowest N270 amplitude. The amplitude of P300 elicited in the match condition decreased in the VPA group compared with other three groups ( P<0.05), but latency of the VPA group was not different from other three groups.ConclusionCognitive impairment is present in epilepsy patients, and the effect of anti-epileptic drug VPA on ability of patients to process conflict is more evidence than CBZ. The sensitivity of N270 to detect early cognitive impairment in epileptics is higher than P300.