| 疏肝健脾方联合拉米呋定治疗肝郁脾虚型慢性乙型肝炎62例临床观察 |
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| 引用本文： | 张盛杰,孙莲娜,薛建华,杜秀萍,王春芳,齐艳艳,明利平,朱敏芳,陈建杰. 疏肝健脾方联合拉米呋定治疗肝郁脾虚型慢性乙型肝炎62例临床观察[J]. 中医杂志, 2010, 51(2) |
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| 作者姓名： | 张盛杰 孙莲娜 薛建华 杜秀萍 王春芳 齐艳艳 明利平 朱敏芳 陈建杰 |
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| 作者单位： | 上海市浦东新区传染病医院传染科,上海市浦东新区华夏东路3018弄46号,201200 |
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| 基金项目： | 上海市卫生局“医学重点专科”科研基金资助项目(05012); 上海市浦东新区卫生系统优秀学科带头人培养项目(PWRD2007-04) |
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| 摘 要： | 目的观察疏肝健脾方联合拉米呋定治疗慢性乙型肝炎(肝郁脾虚型)患者的临床疗效。方法收集肝郁脾虚型慢性乙型肝炎病例180例,其中治疗组62例给予疏肝健脾方联合拉米呋定治疗,对照1组58例单纯服用拉米呋定治疗,对照2组60例单纯服用疏肝健脾方治疗,3组均治疗12个月及随访6个月,观察血清肝功能、HBVDNA定量、乙型肝炎表面抗原(HBeAg)血清学转换、HBVDNA聚合酶活性区发生变异(YMDD变异)发生率、临床证候积分、总有效率等。结果治疗组治疗12个月后丙氨酸氨基转移酶(ALT)改善情况优于对照1组(P0.05);HBeAg阴转率在随访6个月时,治疗组明显高于对照1、2组(P0.05);HBVDNA阴转率,治疗组治疗6个月、12个月和随访6个月均高于两个对照组(P0.05);随访结束时,治疗组HBVDNA阳性患者中YMDD变异检出率低于对照1组(P0.05);治疗组和对照1组、对照2组的总有效率分别为85.5%、65.5%、70.0%,差异有统计学意义(P0.05)。结论疏肝健脾方联合拉米呋定治疗对肝郁脾虚型慢性乙型肝炎患者恢复肝功能、改善临床症状、提高抗病毒疗效、减少拉米呋定耐药的发生均有一定的临床疗效。
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| 关 键 词： | 慢性乙型肝炎 拉米呋定 肝郁脾虚证 疏肝健脾方 临床疗效 |
Clinical Observation on Shugan Jianpi Recipe plus Lamivudine for the Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B Patients: A Report of 62 Cases |
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| ZHANG Shengjie,SUN Lianna,XUE Jianhua,DU Xiuping,WANG Chunfang,QI Yanyan,MING Liping,ZHU Minfang,CHEN Jianjie. Clinical Observation on Shugan Jianpi Recipe plus Lamivudine for the Liver Stagnation and Spleen Deficiency Syndrome in Chronic Hepatitis B Patients: A Report of 62 Cases[J]. Journal of Traditional Chinese Medicine, 2010, 51(2) |
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| Authors: | ZHANG Shengjie SUN Lianna XUE Jianhua DU Xiuping WANG Chunfang QI Yanyan MING Liping ZHU Minfang CHEN Jianjie |
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| Affiliation: | ZHANG Shengjie,SUN Lianna,XUE Jianhua,DU Xiuping,WANG Chunfang,QI Yanyan,MING Liping,ZHU Minfang,CHEN Jianjie(Infectious Disease Hospital of Pudong New Area,Shanghai 201200) |
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| Abstract: | Objective To observe the therapeutic effect of Shugan Jianpi Recipe (Recipe to soothe the liver and strengthen the spleen) plus Lamivudine on the liver stagnation and spleen deficiency syndrome of chronic hepatitis B.Methods Of the 180 patients with chronic hepatits B, 62 patients in the treatment group were prescribed Shugan Jianpi Recipe plus Lamivudine, 58 patients in the control group I were administered Lamivudine only, and 60 patients in the control group II were given Shugan Jianpi Recipe only. All t... |
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| Keywords: | Chronic hepatitis B Lamivudine Liver stagnation and spleen deficiency syndrome Shugan Jianpi Recipe (Recipe to soothe the liver and strengthen the spleen) Therapeutic effect |
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