极后区在动脉血压对间断性冷应激反应中的作用

目的研究延髓极后区(AP)在心血管对应激的反应性中的调节作用.方法雄性Sprague-Dawley大鼠遭到极后区电损毁和间断性冷应激,每天跟踪其尾动脉压(TAP)、食物和水摄入量,持续21天.结果AP损毁引起食物和水摄入一过性减少,但不影响TAP;应激对TAP没有显著性影响;但AP损毁后TAP在应激开始5天后显著性地高于应激前和AP损毁的应激对照组以及假损毁伴应激的大鼠.结论AP在血压对应激的反应性中发挥了重要的调节作用,该作用可能与调节水盐代谢无关.

Role of Area Postrema in Arterial Blood Pressure Response to Intermittent ColdStress

Objective:To investigate the role of area postrema(AP)in response of blood pressure to chronic stress.Methods:Male SD rats were subjected to AP electrolytoc lesion and/or intermittent cold stress.Water and food intake and tail arterial pressure(TAP)were daily monitored.Experiment periods were for 21 days.Results:AP lesion led to transient decreases in food and water intake,not in TAP.Cold stress did not affect TAP in AP intact rats;but could significantly increase TAP in AP lesioned rats,from fifth day after stress,as compared with before stress of after AP lesion without stress of sham with stress.Concluson:AP functions in maintenance of blood pressure homeostasis,which may not be through its regualtion in water and salt metabolism.