腹腔镜和开腹手术剥除卵巢成熟性畸胎瘤对免疫功能的影响

目的：评价使用腹腔镜手术和开腹手术这2种不同术式剥除卵巢成熟性畸胎瘤对患者机体免疫功能的影响，为临床术式的选择提供更多的理论依据。方法收集卵巢成熟性畸胎瘤60例，30例行腹腔镜手术（腹腔镜组），30例行开腹手术（开腹手术组）。比较2组手术情况，检测术前、术后3 d及术后7 d，2组白细胞（WBC）和中性粒细胞（NEU）计数变化、IL-6、TNF-α和Th17细胞水平。结果腹腔镜组手术时间和术中出血量明显少于开腹手术组；2组术后3 d WBC和NEU计数、IL-6、TNF-α和Th17细胞均高于术前，且开腹手术组升高程度显著高于腹腔镜组，差异有统计学意义（P＜0.05）；术后7 d，以上观察指标在2组均有下降趋势，但开腹手术组仍明显高于腹腔镜组（ P＜0.05）。结论对于卵巢成熟性畸胎瘤，采用腹腔镜手术对患者免疫功能影响较小，有利于患者术后恢复。

Comparison of the effect of laparoscopic operation and laparotomy on immune function in divesting ovari-an benign teratoma

Objective To evaluate the effect of laparoscopic operation and laparotomy on immune func -tion in divesting ovarian benign teratoma , and to provide further theoretical evidence for clinical practice .Meth-ods 60 patients with ovarian benign teratoma were selected .30 were conducted by laparoscopic operation （ lapa-roscopic group ） and 30 were conducted by laparotomy （ laparotomy group ） .Operation conditions were compared . White blood cell （WBC） and NEU counts, levels of IL-6,TNF-αand Th17 cells in the 2 groups before surgery, 3 days and 7 days after surgery were detected .Results Surgical time and intraoperative blood loss were signifi-cantly shorter and lower in laparoscopic group than in laparotomy group .Compared to those before surgery , WBC and NEU counts, levels of IL-6, TNF-αand Th17 cells in the two groups increased three days after surgery , and all of these observation targets were much higher in laparotomy group than in laparoscopic group （P〈0.05）.There were downtrends of all the observation targets in two groups 7 days after surgery .However , all the observation tar-gets were still significantly higher in laparotomy group than in laparoscopic group （ P〈0.05） .Conclusion For o-varian benign teratoma , laparoscopic operation had less influence on immune function of patients compared with lap -arotomy, which is better for patients＆#39;recovery.