厄贝沙坦联合氢氯噻嗪治疗老年原发性高血压的临床观察

目的观察厄贝沙坦联合氢氯噻嗪治疗老年原发性高血压的疗效。方法2012年1月～2013年1月在我院住院治疗的老年原发性高血压患者80例，全部入选对象随机分为观察组和对照组，各40例，对照组予厄贝沙坦、观察组同时联合氢氯噻嗪，比较两组的疗效，并记录治疗前后血压的变化情况及用药期间的不良反应情况。结果观察组的总有效率达95．00％，对照组的总有效率达75．00％，两组疗效比较，差异有统计学意义（P〈0．05）。观察组患者的SBP治疗后达（123．82±14．18）mmHg，DBP（85．18±12．37）mmHg，分别与对照组治疗后的SBP、DBP比较，差异有统计学意义（P〈0．05）。结论厄贝沙坦联合氢氯噻嗪治疗老年原发性高血压疗效确切，可以明显降低患者的收缩压、舒张压，且无明显不良反应，值得推广和应用。

Clinical observation of irbesartan combined with hydrochlorothiazide in treatment of elderly patients with primary hypertension

Objective To observe the efficacy of irbesartan combined with hydrochlorothiazide in the treatment of elderly patients with primary hypertension. Methods Eighty elderly patients with primary hypertension who were treated and hospitalized in our hospital from January 2012 to January 2013 were selected as the study subjects and randomly divided into the observation group and the control group, with 40 patients in each group. The control group was given irbesartan and the observation group was given irbesartan combined with hydrochlorothiazide. The efficacy of the two groups was observed and the blood pressure change between before and after treatment and the adverse reactions during medication were recorded. Results The total effective rate of the observation group was 95.00% and that of the control group was 75.00%, with statistically significant difference in the efficacy between the two groups （P 〈 0.05）. In the observation group, the post-treatment SBP reached（123.82 ± 14.18）mm Hg and DBP（85.18± 12.37）mm Hg, which were significantly different from the post-treatment SBP and DBP of the control group respectively （P 〈 0.05）. Conclusion In the treatment of elderly patients with primary hypertension, irbesartan combined with hydrochlorothiazide shows accurate efficacy, can obviously reduce the patients＇ systolic pressure and diastolic pressure, and causes no obvious adverse reactions, thereby worthy of promotion and application.