泮托拉唑和法莫替丁分别联合莫沙必和治疗反流性食管炎的疗效对比

目的探讨泮托拉唑和法莫替丁分别联合莫沙必利治疗反流性食管炎的临床疗效。方法选取我院2013年3月～2014年1月收治的80例反流性食管炎患者，按照不同的治疗方法分为两组：治疗组40例，给予泮托拉唑联合莫沙必利治疗；对照组40例，给予法莫替丁联合莫沙必利。治疗8周后，观察两组疗效及不良反应。结果临床疗效比较，治疗组显效29例，有效10例，无效1例，总有效率为97．5％；对照组显效13例，有效17例，无效10例，总有效率为75．0％，差异具有统计学意义（P〈0．05）。胃镜疗效比较，治疗组痊愈26例，好转12例，无效2例，有效率为95．0％；对照组痊愈17例，好转11例，无效12例，总有效率为70．0％，差异具有统计学意义（P〈0．05）。不良反应比较，差异无明显统计学意义（P〉0．05）。结论泮托拉唑联合莫沙必利治疗RE的疗效明显优于法莫替丁联合莫沙必利，值得在临床推广应用。

Comparison of the efficacy of pantoprazole and famotidine combined with mosapride for treatment of reflux esophagitis

Objective To explore the clinical efficacy of Pantoprazole and Famotidine combined with Mosapride for reflux esophagitis. Methods 80 cases of reflux esophagitis admitted and treated in our hospital from Mar 2013 to Jan 2014 were assigned to two groups according to the treatment methods： the treatment group （40 cases） given Pantoprazole combined with Mosapride and the control group（40 cases） given Famotidine combined with Mosapride. The efficacy and adverse reaction of the two groups were observed after treatment for 8 weeks. Results When comparing the clinical efficacy,29,10 and 1 case of the treatment group had significant efficacy,efficacy and no response respectively,with total effective rate of 97.5%;13,17 and 10 cases of the control group had significant efficacy,efficacy and no response respectively,with total effective rate of 75.0%, with statistical significance （P 〈 0.05）. When comparing the efficacy observed under gastroscopy,26,12 and 2 cases of the treatment group were cured,improved and ineffective respectively, with effective rate of 95.0%;17,11 and 12 cases of the control group were cured,improved and ineffective respectively,with effective rate of 70.0%,with statistical significance（P 〈 0.05）. When comparing adverse reactions,the difference between the two groups had no statistical significance（P =〉 0.05）. Conclusion Pantoprazole combined with Mosapride has better efficacy for reflux esophagitis than Famotidine combined with Mosapride,which is worthy of clinical promotion and application.