儿童沙门菌感染44例流行病学特征和耐药分析

目的了解近年本地区儿童沙门菌感染的流行病学特征和耐药性。方法回顾分析本院微生物室2008～2012年从儿科分离到的临床确诊为沙门菌感染的沙门菌株及临床资料。结果44株沙门菌主要分离自〈1岁婴幼儿（占59．09％）。共分8种血清型，鼠伤寒沙门菌为主要血清型（占65．91％）。鼠伤寒沙门菌对亚胺培南、头孢他啶、头孢曲松、头孢噻肟敏感率分别为100．00％、100．00％、96．56％、96．56％；对氨苄西林，复方新诺明、哌拉西林、环丙沙星敏感率分别24．14％、41．38％、41．38％、55．17％。结论本地区儿童沙门菌感染以婴幼儿鼠伤寒沙门菌感染为主。鼠伤寒沙门菌对亚胺培南、三代头孢菌素敏感率高，对氨苄西林、复方新诺明、哌拉西林、环丙沙星敏感率低。

An analysis of epidemiological characteristics and drug resistance of 44 cases of children Salmonella infections

Objective To understand the epidemiological characteristics and drug resistance of children Salmonella infections in this area in recent years. Methods Salmonella strains of clinically diagnosed Salmonella infections which were extracted from the department of pediatrics and patients＇clinical data from 2008 to 2012 in the microbiology laboratory in our hospital were analyzed retrospectively, Results 44 Salmonella strains were mainly extracted from infants less than one year old （59.09%）.There were eight serotypes,and Salmonella typhimurium was the main serotype （65.91%）.The sensitivity of Salmonella typhimurium towards imipenem,ceftazidime,ceftriaxone and cefotaxime were 100.00%,100.00%,96.56% and 96.56% respectively;its sensitivity towards ampicillin, trimethoprim/ sulfamethoxazole,piperaeillin and eiprofloxacin were 24.14%,41.38%,41.38% and 55.17% respectively. Conclusion The majority of children Salmonella infections in this area are infant infections of Salmonella typhimurium.The Salmonella typhimurium has a high sensitivity to imipenem and the third generation cephalosporins,and a low sensitivity to ampicillin,trimethoprim/sulfamethoxazole,piperacillin and ciprofloxacin.