Whole-pulmonary low-dose radiation therapy in agnogenic myeloid metaplasia with diffuse lung involvement |
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Authors: | Weinschenker Patrícia Kutner José M Salvajoli João V Hanriot Rodrigo M Ribeiro Andressa F Capelozzi Vera L Del Giglio Auro |
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Affiliation: | Division of Hematology and Oncology, ABC Foundation School of Medicine, S?o Paulo, Brazil. |
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Abstract: | Agnogenic myeloid metaplasia is a hematologic disorder accompanied by extramedullary hematopoiesis (EMH) affecting various organs. Lung involvement however is rare. We present the case of a 76-year-old woman with myelofibrosis, recurrent pleural effusions, pulmonary hypertension, and serious right cardiac failure. An open lung biopsy confirmed pulmonary EMH. She underwent low-dose (200 cGy) whole-lung radiotherapy in 4 fractions of 50 cGy each. Her clinical and hemodynamic parameters improved. We conclude that low-dose whole-lung radiation may be efficacious for the palliative treatment of pulmonary EMH. |
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Keywords: | agnogenic myeloid metaplasia extramedulary hematopoiesis low‐dose whole‐lung radiation |
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