胰腺癌环氧合酶-2表达的意义

目的研究胰腺癌中COX-2表达的意义．方法应用免疫组化SP法检测82例胰腺癌、22例慢性胰腺炎、9例胰腺良性肿瘤、15例正常胰腺组织和2株人胰腺癌细胞中COX-2的表达，然后比较胰腺癌组织COX-2表达与胰腺癌患者临床病理特征的关系。结果2株人胰腺癌细胞COX-2表达均阳性。70．7％（58／82）胰腺癌组织可见COX-2表达，而正常胰腺组织只有6．7％（1／15）呈微弱表达。COX-2在4种组织中的表达程度有显著性差异（P〈0．001）。胰腺癌组织COX-2表达显著高于其他3种组织（P〈0．05）。胰腺癌组织COX-2表达水平的高低与胰腺癌的临床病理特征无关（P〉0．05）。结论COX-2蛋白的检测对胰腺癌的诊断及其与胰腺良性肿瘤、慢性胰腺炎的鉴别诊断有帮助。胰腺癌组织COX-2表达不能作为预测患者预后的指标。

Significance of cyciooxygenase-2 expression in pancreatic cancer

Objective To investigate the significance of cyclooxygenase-2 （COX-2） expression in pancreatic cancer. Methods COX-2 expression was measured in tissue specimens from 82 patients with pancreatic cancer, 22 chronic pancreatitis, 9 benign pancreatic tumors and 15 normal pancreatic tissues, and 2 human pancreatic cancer cell lines using immunohistochemistry. COX-2 expression in pancreatic cancer tissue and elinicopathological features were compared. Results COX-2 expression was found in 2 human pancreatic cancer cell lines. COX-2 expression was found in 70.7% （58/82） of patients with pancreatic cancer, but it was not detected or weakly expressed in 6.7% （1/15） of normal pancreatic tissues. There was significant difference of COX-2 expression among the above four groups （P 〈 0. 001 ）. COX-2 expression in pancreatic cancer was significantly higher than that in other three tissues （P 〈 0.05）. COX-2 expression in pancreatic cancer tissue showed no correlation with clinicopathological features of patients with cancers （P 〉 0.05）. Conclusion COX-2 over-expression might play an important role in the carcinogenesis and development of pancreatic cancer. The determination of COX-2 expression might be valuable for the diagnosis of pancreatic cancer and differential diagnosis of pancreatic cancer from benign pancreatic tumors and chronic pancreatitis. The COX- 2 expression in pancreatic cancer tissue could not be used as a parameter for predicting the prognosis of the patient. COX-2 inhibitors might be potentially effective for prevention and treatment of pancreatic cancer.