The effect of lead exposure on some inflammatory biomarkers of lung lavage fluid in rats |
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| Authors: | Tahereh Farkhondeh Mohsen Azimi-Nezhad |
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| Affiliation: | 1. Immunogenetic and Cell Culture Department, Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,;2. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran, and;3. Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | This study was designed to examine the association between lead exposure and inflammatory responses in the lung lavage of rats. Thirty rats were randomly allocated into control (group C), sensitized (group S), and three exposed to lead (Pb) (groups 0.1M Pb and 0.4M Pb). Animal were sensitized with i.p. injected and aerosolized ovalbumin (OA). Pb-exposed groups inhaled 0.1M and 0.4M lead acetate for 1?h, thrice a week for two weeks. The levels of total protein, IgE and histamine were measured in the lung lavage of rats. The results of the present study showed significant increase in the levels of total protein, IgE and histamine in the lung lavage of rats exposed to high lead concentration and that of total protein and histamine in animal exposed to low lead concentration compared to control animals. The similar findings were also observed in sensitized animals. In addition, the levels of IgE and histamine in lung lavage of group exposed to high lead concentration significantly increased compared to group exposed to low lead concentration. The findings of the present study showed that exposure to inhaled lead acetate may lead to asthma like disease via inducing inflammatory responses in the lung lavage of rats. |
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| Keywords: | Lead exposure inflammatory biomarkers lung lavage rats |
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