In situ effect of a CPP-ACP chewing gum on enamel erosion associated or not with abrasion |
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Authors: | de Oliveira Andressa Feitosa Bezerra de Oliveira Diniz Luciana Vilar Forte Franklin Delano Soares Sampaio Fabio Correia Ccahuana-Vásquez Renzo Alberto Tochukwu Amaechi Bennett |
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Institution: | 1.Health Science Center, Federal University of Paraíba, Campus I – Cidade Universitária, s/n Castelo Branco, Joâo Pessoa, Paraíba, 58.051-900, Brazil ;2.University Centre of João Pessoa (UNIPÊ), Rodovia BR 230 - Km 22, s/n, Água Fria, João Pessoa, Paraíba, 58053-000, Brazil ;3.Braun GmbH, German Innovation Center Campus Kronberg, Frankfurter Strasse, 145 61476, Kronberg, Germany ;4.University of Texas Health Science Center, San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA ; |
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Abstract: | Objectives The purpose of this study is to analyze the in situ effect of a casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP) chewing gum on human enamel erosion lesion associated or not with abrasion. Material and methodsA three-way crossover study of 7 days was conducted involving 10 volunteers subjected to the same protocol: (G1) CPP-ACP sugar-free chewing gum, (G2) regular sugar-free chewing gum without CPP-ACP, and (G3) saliva—no chewing gum. An abrasion test was included in each phase. A 3D non-contact profilometry measurement of lesion depth and surface roughness was obtained of sound and eroded surfaces. A salivary calcium concentration was determined for all volunteers. ANOVA followed by Tukey’s test were used with a p < 0.05. ResultsThe enamel depth and the enamel surface roughness of the CPP-ACP gum group were significantly lower than the others (ANOVA, p < 0.05). No significant differences were observed between the treatments when associated with abrasion (p > 0.05). A positive and significant correlation was seen between the lesion depth and enamel surface roughness for GI (r = 0.87, p = 0.00) and GIII (r = 0.79, p = 0.00) groups. The estimated total calcium presented in the saliva after the chewed CPP-ACP gum showed no statistical significance between the mean absorbance values at the different time collections (p > 0.05). ConclusionsIt is demonstrated that the incorporation of the CPP-ACP into a sugar-free gum significantly increased the remineralization/protection of eroded enamel surface. Clinical relevanceThe CPP-ACP added to gum may be a suitable alternative vehicle, to deliver calcium ions to saliva and therefore protecting enamel. |
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