益生菌治疗妊娠期便秘疗效的Meta分析

目的系统评价益生菌治疗妊娠期便秘的临床疗效。方法检索PubMed,Embase,The Cochrane Library,ClinicalTrials.gov,CBM,中文科技期刊全文数据库(VIP),中国知网(CNKI),万方数据库(WanFang Data),收集关于益生菌治疗妊娠期便秘的随机对照试验(RCTs),检索时间均从自建库至2018年12月。由2位研究员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入5个RCTs,752例患者;Meta分析结果显示,益生菌组的总有效率高于对照组OR=6.01,95%CI(2.05,17.64),P=0.001];与基线比较,益生菌组每周增加排便次数多于对照组MD=3.07,95%CI(2.45,3.68),P<0.00001];亚组分析显示,双歧杆菌能增加每周排便频次。结论益生菌可有效治疗妊娠期便秘,增加妊娠期便秘患者的每周排便频次。

Meta-Analysis on the Efficacy of Probiotics for Constipation During Pregnancy

Objective To evaluate the efficacy of probiotics in the treatment of constipation during pregnancy.Methods Databases including PubMed,EMbase,The Cochrane Library,Clinical Trials.gov,CBM,VIP,CNKI and WanFang Data were electronically searched from inception to December 2018 to collect randomized controlled trials(RCTs)on probiotics in the treatment of constipation during pregnancy.Two reviewers independently screened literature,extracted data,and assessed risk of bias of included studies.Meta-analysis was performed by using RevMan 5.3 software.Results A total of 5 RCTs involving 752 patients were included.The results of meta-analysis showed that:compared with control group,the probiotics more efficiently in the total effective rateOR=6.01,95%CI(2.05,17.64),P=0.001].Compared with the baseline,the number of defecations per week in probiotics groupMD=3.07,95%CI(2.45,3.68),P<0.00001]was better than that in control group.Subgroup analysis showed that bifidobacterium could increase the weekly frequency of defecation during pregnancy.Conclusion Probiotics can effectively treat constipation during pregnancy and increase the weekly frequency of stool in patients with constipation during pregnancy.